MYC

Information MYC

Description

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Full Name

myelocytomatosis oncogene

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
59
Biotypes
20
Peaks
894,411
Non-redundant peaks
285,329

TF Classification

Familly
Basic helix-loop-helix factors (bHLH)
Sub Familly
bHLH-ZIP factors

Source JASPAR

External IDs

NCBI Gene
17869
Official Gene Name
Myc
JASPAR
MA0147.2
MGI
MGI:97250
Ensembl
ENSMUSG00000022346
UniProt
P01108
Genevisible
P01108
RefSeq
NM_010849
Aliases
AU016757; Myc2; Niard; Nird; bHLHe39; c-myc
All peaks MYC
Download BED file
Non redundant peaks MYC
Download BED file
SEQUENCES MYC
Download FASTA file
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Datasets Table for MYC

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MYC EpH4 GEO Mus musculus GSE98002 782
MYC liver tet-Myc GEO Mus musculus GSE76042 8,453
MYC liver WT GEO Mus musculus GSE76042 18,196
MYC liver TetYapMyc GEO Mus musculus GSE83863 37,745
MYC liver TetYap GEO Mus musculus GSE83863 30,427
MYC liver GEO Mus musculus GSE83863 37,783
MYC pre-iPSC GEO Mus musculus GSE90893 56,717
MYC cornea GEO Mus musculus GSE49409 3,962
MYC MEF GEO Mus musculus GSE102517 8,274
MYC MEF endo GEO Mus musculus GSE90893 32,475
MYC MEF 48h GEO Mus musculus GSE90893 24,326
MYC MEF GEO Mus musculus GSE109458 11,402
MYC MEF PIN1-KO GEO Mus musculus GSE109458 9,338
MYC lymphoma GEO Mus musculus GSE60223 24,439
MYC lymphocyte GEO Mus musculus GSE44672 32,751
MYC primary-B-cell Tg GEO Mus musculus GSE51004 49,368
MYC primary-B-cell GEO Mus musculus GSE51004 18,611
MYC mESC Taf6l-KO GEO Mus musculus GSE113334 5,052
MYC mESC GEO Mus musculus GSE90893 4,534
MYC mESC GEO Mus musculus GSE43229 4,191
MYC mESC KDM4B-KO GEO Mus musculus GSE43229 4,790
MYC mESC Zfp281-sh10 GEO Mus musculus GSE125435 3,568
MYC mESC Taf5l-KO GEO Mus musculus GSE113334 9,551
MYC mESC GEO Mus musculus GSE113334 623
MYC mESC Dnmt1 GEO Mus musculus GSE77779 17,123
MYC mESC Dox_1d GEO Mus musculus GSE133899 683
MYC hindbrain GEO Mus musculus GSE74315 3,384
MYC lung-cancer PB120 GEO Mus musculus GSE87034 16,036
MYC lung-cancer PB119 GEO Mus musculus GSE87034 33,353
MYC lung-cancer PB115 GEO Mus musculus GSE87034 20,325
MYC BMDM IFNg-2h GEO Mus musculus GSE84518 5,145
MYC BMDM UT GEO Mus musculus GSE84518 1,081
MYC neuron GEO Mus musculus GSE77213 100
MYC lymphoma veh GEO Mus musculus GSE94130 23,667
MYC lymphoma GEO Mus musculus GSE83778 2,511
MYC lymphoma JQ1 GEO Mus musculus GSE94130 30,435
MYC fibroblast OHT-4h GEO Mus musculus GSE51004 41,708
MYC fibroblast OHT-0h GEO Mus musculus GSE51004 27,645
MYC BMDM IL4-2h GEO Mus musculus GSE84518 16,633
MYC BMDM IFNg-IL4-4h GEO Mus musculus GSE84518 5,427
MYC BMDM IL4-4h GEO Mus musculus GSE84518 12,836
MYC MEL ENCODE Mus musculus ENCSR000EUA 20,535
MYC MEF GEO Mus musculus GSE44672 25,017
MYC MEF d7 GEO Mus musculus GSE102517 3,628
MYC MEF d1 GEO Mus musculus GSE102517 3,869
MYC MEF d3 GEO Mus musculus GSE102517 917
MYC MEF d2 GEO Mus musculus GSE102517 3,064
MYC NPC GEO Mus musculus GSE48602 268
MYC iPSC GEO Mus musculus GSE102517 4,880
MYC liver TetMyc GEO Mus musculus GSE83863 41,762
MYC liver LAPtTA GEO Mus musculus GSE76042 9,717
MYC CH12-LX ENCODE Mus musculus ENCSR000ERN 17,453
MYC B-cell GEO Mus musculus GSE80669 1,343
MYC mESC KDM4C-KO GEO Mus musculus GSE43229 3,920
MYC mESC GEO Mus musculus GSE48175 4,032
MYC mESC GEO Mus musculus GSE125435 27,203
MYC pancreas GEO Mus musculus GSE44672 17,121
MYC pancreas GEO Mus musculus GSE77409 4,108
MYC EpH4 DMSO GEO Mus musculus GSE98002 10,124
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks