MYC
Information MYC
- Description
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
- Full Name
myelocytomatosis oncogene
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 59
- Biotypes
- 20
- Peaks
- 894,411
- Non-redundant peaks
- 285,329
TF Classification
- Familly
- Basic helix-loop-helix factors (bHLH)
- Sub Familly
- bHLH-ZIP factors
Source JASPAR
Datasets Table for MYC
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
MYC | EpH4 | GEO | Mus musculus | GSE98002 | 782 | |||
MYC | liver | tet-Myc | GEO | Mus musculus | GSE76042 | 8,453 | ||
MYC | liver | WT | GEO | Mus musculus | GSE76042 | 18,196 | ||
MYC | liver | TetYapMyc | GEO | Mus musculus | GSE83863 | 37,745 | ||
MYC | liver | TetYap | GEO | Mus musculus | GSE83863 | 30,427 | ||
MYC | liver | GEO | Mus musculus | GSE83863 | 37,783 | |||
MYC | pre-iPSC | GEO | Mus musculus | GSE90893 | 56,717 | |||
MYC | cornea | GEO | Mus musculus | GSE49409 | 3,962 | |||
MYC | MEF | GEO | Mus musculus | GSE102517 | 8,274 | |||
MYC | MEF | endo | GEO | Mus musculus | GSE90893 | 32,475 | ||
MYC | MEF | 48h | GEO | Mus musculus | GSE90893 | 24,326 | ||
MYC | MEF | GEO | Mus musculus | GSE109458 | 11,402 | |||
MYC | MEF | PIN1-KO | GEO | Mus musculus | GSE109458 | 9,338 | ||
MYC | lymphoma | GEO | Mus musculus | GSE60223 | 24,439 | |||
MYC | lymphocyte | GEO | Mus musculus | GSE44672 | 32,751 | |||
MYC | primary-B-cell | Tg | GEO | Mus musculus | GSE51004 | 49,368 | ||
MYC | primary-B-cell | GEO | Mus musculus | GSE51004 | 18,611 | |||
MYC | mESC | Taf6l-KO | GEO | Mus musculus | GSE113334 | 5,052 | ||
MYC | mESC | GEO | Mus musculus | GSE90893 | 4,534 | |||
MYC | mESC | GEO | Mus musculus | GSE43229 | 4,191 | |||
MYC | mESC | KDM4B-KO | GEO | Mus musculus | GSE43229 | 4,790 | ||
MYC | mESC | Zfp281-sh10 | GEO | Mus musculus | GSE125435 | 3,568 | ||
MYC | mESC | Taf5l-KO | GEO | Mus musculus | GSE113334 | 9,551 | ||
MYC | mESC | GEO | Mus musculus | GSE113334 | 623 | |||
MYC | mESC | Dnmt1 | GEO | Mus musculus | GSE77779 | 17,123 | ||
MYC | mESC | Dox_1d | GEO | Mus musculus | GSE133899 | 683 | ||
MYC | hindbrain | GEO | Mus musculus | GSE74315 | 3,384 | |||
MYC | lung-cancer | PB120 | GEO | Mus musculus | GSE87034 | 16,036 | ||
MYC | lung-cancer | PB119 | GEO | Mus musculus | GSE87034 | 33,353 | ||
MYC | lung-cancer | PB115 | GEO | Mus musculus | GSE87034 | 20,325 | ||
MYC | BMDM | IFNg-2h | GEO | Mus musculus | GSE84518 | 5,145 | ||
MYC | BMDM | UT | GEO | Mus musculus | GSE84518 | 1,081 | ||
MYC | neuron | GEO | Mus musculus | GSE77213 | 100 | |||
MYC | lymphoma | veh | GEO | Mus musculus | GSE94130 | 23,667 | ||
MYC | lymphoma | GEO | Mus musculus | GSE83778 | 2,511 | |||
MYC | lymphoma | JQ1 | GEO | Mus musculus | GSE94130 | 30,435 | ||
MYC | fibroblast | OHT-4h | GEO | Mus musculus | GSE51004 | 41,708 | ||
MYC | fibroblast | OHT-0h | GEO | Mus musculus | GSE51004 | 27,645 | ||
MYC | BMDM | IL4-2h | GEO | Mus musculus | GSE84518 | 16,633 | ||
MYC | BMDM | IFNg-IL4-4h | GEO | Mus musculus | GSE84518 | 5,427 | ||
MYC | BMDM | IL4-4h | GEO | Mus musculus | GSE84518 | 12,836 | ||
MYC | MEL | ENCODE | Mus musculus | ENCSR000EUA | 20,535 | |||
MYC | MEF | GEO | Mus musculus | GSE44672 | 25,017 | |||
MYC | MEF | d7 | GEO | Mus musculus | GSE102517 | 3,628 | ||
MYC | MEF | d1 | GEO | Mus musculus | GSE102517 | 3,869 | ||
MYC | MEF | d3 | GEO | Mus musculus | GSE102517 | 917 | ||
MYC | MEF | d2 | GEO | Mus musculus | GSE102517 | 3,064 | ||
MYC | NPC | GEO | Mus musculus | GSE48602 | 268 | |||
MYC | iPSC | GEO | Mus musculus | GSE102517 | 4,880 | |||
MYC | liver | TetMyc | GEO | Mus musculus | GSE83863 | 41,762 | ||
MYC | liver | LAPtTA | GEO | Mus musculus | GSE76042 | 9,717 | ||
MYC | CH12-LX | ENCODE | Mus musculus | ENCSR000ERN | 17,453 | |||
MYC | B-cell | GEO | Mus musculus | GSE80669 | 1,343 | |||
MYC | mESC | KDM4C-KO | GEO | Mus musculus | GSE43229 | 3,920 | ||
MYC | mESC | GEO | Mus musculus | GSE48175 | 4,032 | |||
MYC | mESC | GEO | Mus musculus | GSE125435 | 27,203 | |||
MYC | pancreas | GEO | Mus musculus | GSE44672 | 17,121 | |||
MYC | pancreas | GEO | Mus musculus | GSE77409 | 4,108 | |||
MYC | EpH4 | DMSO | GEO | Mus musculus | GSE98002 | 10,124 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |