MYOG

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. {ECO:0000269|PubMed:15706034, ECO:0000269|PubMed:16407395, ECO:0000269|PubMed:16424906, ECO:0000269|PubMed:16437161, ECO:0000269|PubMed:21465538, ECO:0000269|PubMed:21798092, ECO:0000269|PubMed:22235349, ECO:0000269|PubMed:22847234, ECO:0000269|PubMed:23364797, ECO:0000269|PubMed:8393145, ECO:0000269|PubMed:8393146}.(Source UnitProtKB).

myogenin

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10