MYT1L
Information MYT1L
- Description
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941). {ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220, ECO:0000269|PubMed:28379941, ECO:0000269|PubMed:9130664, ECO:0000269|PubMed:9373037}.(Source UnitProtKB).
- Full Name
myelin transcription factor 1-like
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 1
- Peaks
- 118,637
- Non-redundant peaks
- 90,249
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17933
- Official Gene Name
- Myt1l
- JASPAR
- MGI
- MGI:1100511
- Ensembl
- ENSMUSG00000061911
- UniProt
- P97500
- Genevisible
- P97500
- RefSeq
- NM_008666
- Aliases
- 2900046C06Rik; 2900093J19Rik; C630034G21Rik; Nztf1; Pmng1; Png-1; mKIAA1106
Datasets Table for MYT1L
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MYT1L | MEF | Mytl1b_BAtruncflM | GEO | Mus musculus | GSE72121 | 15,264 | ||
| MYT1L | MEF | Mytl1b_truncflM | GEO | Mus musculus | GSE72121 | 45,535 | ||
| MYT1L | MEF | Mytl1b_BAflM | GEO | Mus musculus | GSE72121 | 13,609 | ||
| MYT1L | MEF | Mytl1a_BAflM | GEO | Mus musculus | GSE72121 | 4,896 | ||
| MYT1L | MEF | BAM | GEO | Mus musculus | GSE43916 | 321 | ||
| MYT1L | MEF | Mytl1b_flM | GEO | Mus musculus | GSE72121 | 39,012 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |