NCOA2
Information NCOA2
- Description
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:24529706). {ECO:0000269|PubMed:11997499, ECO:0000269|PubMed:12507421, ECO:0000269|PubMed:16148126, ECO:0000269|PubMed:19039140, ECO:0000269|PubMed:24529706}.(Source UnitProtKB).
- Full Name
nuclear receptor coactivator 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 3
- Peaks
- 188,401
- Non-redundant peaks
- 140,076
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17978
- Official Gene Name
- Ncoa2
- JASPAR
- MGI
- MGI:1276533
- Ensembl
- ENSMUSG00000005886
- UniProt
- Q61026
- Genevisible
- Q61026
- RefSeq
- NM_008678
- Aliases
- D1Ertd433e; GRIP-1; Grip1; KAT13C; NCoA-2; SRC-2; TIF-2; TIF2; TIF2/GRIP-1; bHLHe75; glucocorticoid receptor-interacting protein 1
Datasets Table for NCOA2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NCOA2 | liver | ZT4 | GEO | Mus musculus | GSE53039 | 43,357 | ||
| NCOA2 | liver | KO | GEO | Mus musculus | GSE53039 | 25,825 | ||
| NCOA2 | prostate | GEO | Mus musculus | GSE54770 | 16,451 | |||
| NCOA2 | BMDM | Dex | GEO | Mus musculus | GSE99887 | 59,977 | ||
| NCOA2 | BMDM | GEO | Mus musculus | GSE99887 | 1,895 | |||
| NCOA2 | liver | ZT18 | GEO | Mus musculus | GSE53039 | 40,896 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |