NCOA2

Information NCOA2

Description

The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Full Name

nuclear receptor coactivator 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
7
Biotypes
4
Peaks
83,972
Non-redundant peaks
75,046

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
10499
Official Gene Name
NCOA2
JASPAR
Ensembl
ENSG00000140396
UniProt
Q15596
Genevisible
Q15596
RefSeq
NM_001321703
Aliases
GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75
All peaks NCOA2
Download BED file
Non redundant peaks NCOA2
Download BED file
SEQUENCES NCOA2
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for NCOA2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NCOA2 pS469 THP-1 Dex GEO Homo sapiens GSE99887 317
NCOA2 THP-1 Dex GEO Homo sapiens GSE99887 2,972
NCOA2 MCF-7 ENA Homo sapiens ERP000901 28,332
NCOA2 MCF-7 E2 ENA Homo sapiens ERP000901 48,630
NCOA2 K-562 ENCODE Homo sapiens ENCSR803EKW 1,132
NCOA2 K-562 ENCODE Homo sapiens ENCSR349TZO 1,207
NCOA2 hESC GEO Homo sapiens GSE123246 1,382
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks