NCOA2
Information NCOA2
- Description
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
- Full Name
nuclear receptor coactivator 2
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 7
- Biotypes
- 4
- Peaks
- 83,972
- Non-redundant peaks
- 75,046
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 10499
- Official Gene Name
- NCOA2
- JASPAR
- Ensembl
- ENSG00000140396
- UniProt
- Q15596
- Genevisible
- Q15596
- RefSeq
- NM_001321703
- Aliases
- GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75
Datasets Table for NCOA2
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
NCOA2 | pS469 | THP-1 | Dex | GEO | Homo sapiens | GSE99887 | 317 | |
NCOA2 | THP-1 | Dex | GEO | Homo sapiens | GSE99887 | 2,972 | ||
NCOA2 | MCF-7 | ENA | Homo sapiens | ERP000901 | 28,332 | |||
NCOA2 | MCF-7 | E2 | ENA | Homo sapiens | ERP000901 | 48,630 | ||
NCOA2 | K-562 | ENCODE | Homo sapiens | ENCSR803EKW | 1,132 | |||
NCOA2 | K-562 | ENCODE | Homo sapiens | ENCSR349TZO | 1,207 | |||
NCOA2 | hESC | GEO | Homo sapiens | GSE123246 | 1,382 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |