NCOR1
Information NCOR1
- Description
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (PubMed:24794873). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247). {ECO:0000250|UniProtKB:O75376, ECO:0000269|PubMed:19037247, ECO:0000269|PubMed:24794873}.
- Full Name
nuclear receptor co-repressor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 10
- Biotypes
- 4
- Peaks
- 299,106
- Non-redundant peaks
- 168,318
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20185
- Official Gene Name
- Ncor1
- JASPAR
- MGI
- MGI:1349717
- Ensembl
- ENSMUSG00000018501
- UniProt
- Q60974
- Genevisible
- Q60974
- RefSeq
- NM_177229
- Aliases
- 5730405M06Rik; A230020K14Rik; N-CoR; RIP13; Rxrip13; mKIAA1047
Datasets Table for NCOR1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NCOR1 | liver | ZT22 | GEO | Mus musculus | GSE26345 | 2,305 | ||
| NCOR1 | liver | T3 | GEO | Mus musculus | GSE128535 | 35,882 | ||
| NCOR1 | liver | ZT10 | GEO | Mus musculus | GSE26345 | 22,005 | ||
| NCOR1 | cortical-neuron | GEO | Mus musculus | GSE66701 | 3,739 | |||
| NCOR1 | cortical-neuron | Reelin | GEO | Mus musculus | GSE66701 | 185 | ||
| NCOR1 | preadipocyte | 4h | GEO | Mus musculus | GSE95533 | 61,383 | ||
| NCOR1 | 3T3-L1 | rosi | GEO | Mus musculus | GSE56745 | 44,176 | ||
| NCOR1 | preadipocyte | D0 | GEO | Mus musculus | GSE95533 | 57,369 | ||
| NCOR1 | liver | GEO | Mus musculus | GSE128535 | 41,524 | |||
| NCOR1 | 3T3-L1 | GEO | Mus musculus | GSE56745 | 30,538 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |