NCOR1

Information NCOR1

Description

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (PubMed:24794873). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247). {ECO:0000250|UniProtKB:O75376, ECO:0000269|PubMed:19037247, ECO:0000269|PubMed:24794873}.

Full Name

nuclear receptor co-repressor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
10
Biotypes
4
Peaks
299,106
Non-redundant peaks
168,318

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20185
Official Gene Name
Ncor1
JASPAR
MGI
MGI:1349717
Ensembl
ENSMUSG00000018501
UniProt
Q60974
Genevisible
Q60974
RefSeq
NM_177229
Aliases
5730405M06Rik; A230020K14Rik; N-CoR; RIP13; Rxrip13; mKIAA1047
All peaks NCOR1
Download BED file
Non redundant peaks NCOR1
Download BED file
SEQUENCES NCOR1
Download FASTA file
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Datasets Table for NCOR1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NCOR1 liver ZT22 GEO Mus musculus GSE26345 2,305
NCOR1 liver T3 GEO Mus musculus GSE128535 35,882
NCOR1 liver ZT10 GEO Mus musculus GSE26345 22,005
NCOR1 cortical-neuron GEO Mus musculus GSE66701 3,739
NCOR1 cortical-neuron Reelin GEO Mus musculus GSE66701 185
NCOR1 preadipocyte 4h GEO Mus musculus GSE95533 61,383
NCOR1 3T3-L1 rosi GEO Mus musculus GSE56745 44,176
NCOR1 preadipocyte D0 GEO Mus musculus GSE95533 57,369
NCOR1 liver GEO Mus musculus GSE128535 41,524
NCOR1 3T3-L1 GEO Mus musculus GSE56745 30,538
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks