NCOR2
Information NCOR2
- Description
Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. {ECO:0000250|UniProtKB:Q9Y618, ECO:0000269|PubMed:19144721}.(Source UnitProtKB).
- Full Name
nuclear receptor co-repressor 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 14
- Biotypes
- 3
- Peaks
- 543,428
- Non-redundant peaks
- 198,224
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20602
- Official Gene Name
- Ncor2
- JASPAR
- MGI
- MGI:1337080
- Ensembl
- ENSMUSG00000029478
- UniProt
- Q9WU42
- Genevisible
- Q9WU42
- RefSeq
- NM_011424
- Aliases
- N-CoR; SMRT; SMRTe
Datasets Table for NCOR2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NCOR2 | liver | ZT22 | GEO | Mus musculus | GSE51045 | 62,577 | ||
| NCOR2 | embryonic-cortical-culture | 2kcl_ctlshrna | GEO | Mus musculus | GSE121660 | 66,903 | ||
| NCOR2 | embryonic-cortical-culture | 2kcl_ncor2shrna | GEO | Mus musculus | GSE121660 | 58,265 | ||
| NCOR2 | embryonic-cortical-culture | 2kcl_a2shrna | GEO | Mus musculus | GSE121660 | 34,204 | ||
| NCOR2 | embryonic-cortical-culture | 0kcl_ctlshrna | GEO | Mus musculus | GSE121660 | 39,001 | ||
| NCOR2 | embryonic-cortical-culture | 1kcl | GEO | Mus musculus | GSE121660 | 19,254 | ||
| NCOR2 | embryonic-cortical-culture | 0kcl_a2shrna | GEO | Mus musculus | GSE121660 | 23,114 | ||
| NCOR2 | embryonic-cortical-culture | 0kcl_ncor2shrna | GEO | Mus musculus | GSE121660 | 3,227 | ||
| NCOR2 | embryonic-cortical-culture | 2kcl_milipore | GEO | Mus musculus | GSE121660 | 40,494 | ||
| NCOR2 | embryonic-cortical-culture | 0kcl | GEO | Mus musculus | GSE121660 | 66,843 | ||
| NCOR2 | embryonic-cortical-culture | 0kcl_a2shrna_mili | GEO | Mus musculus | GSE121660 | 52,710 | ||
| NCOR2 | BMDM | GEO | Mus musculus | GSE66501 | 315 | |||
| NCOR2 | embryonic-cortical-culture | 5kcl | GEO | Mus musculus | GSE121660 | 18,750 | ||
| NCOR2 | liver | ZT10 | GEO | Mus musculus | GSE51045 | 57,771 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |