NELFA

Information NELFA

Description

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]

Full Name

negative elongation factor complex member A

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
15
Biotypes
3
Peaks
133,472
Non-redundant peaks
30,082

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
7469
Official Gene Name
NELFA
JASPAR
Ensembl
ENSG00000185049
UniProt
Q9H3P2
Genevisible
Q9H3P2
RefSeq
NM_005663
Aliases
NELF-A; P/OKcl.15; WHSC2
All peaks NELFA
Download BED file
Non redundant peaks NELFA
Download BED file
SEQUENCES NELFA
Download FASTA file
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Datasets Table for NELFA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NELFA BT-474 INHHDAC ENA Homo sapiens ERP010664 12,051
NELFA BT-474 ENA Homo sapiens ERP010664 5,558
NELFA HeLa Flavo-PJ34-10min-H2O2 GEO Homo sapiens GSE100742 6,922
NELFA HeLa 40min-Flavo-0-H2O2 GEO Homo sapiens GSE93931 5,149
NELFA HeLa Flavo-0-H2O2 GEO Homo sapiens GSE100742 9,473
NELFA HeLa Flavo-35min-H2O2 GEO Homo sapiens GSE100742 11,987
NELFA HeLa 40min-Flavo-PJ34-10min-H2O2 GEO Homo sapiens GSE93931 6,922
NELFA HeLa 1h-Flavo-0-H2O2 GEO Homo sapiens GSE93931 9,349
NELFA HeLa 40min-Flavo-10min-H2O2 GEO Homo sapiens GSE93931 4,213
NELFA HeLa 40min-Flavo-PJ34-0-H2O2 GEO Homo sapiens GSE93931 5,994
NELFA HeLa Flavo-10min-H2O2 GEO Homo sapiens GSE100742 4,213
NELFA HeLa Flavo-PJ34-0-H2O2 GEO Homo sapiens GSE100742 5,994
NELFA HeLa 1h_Flavo-35min-H2O2 GEO Homo sapiens GSE93931 11,763
NELFA K-562 NHS GEO Homo sapiens GSE112379 15,477
NELFA K-562 HS GEO Homo sapiens GSE112379 18,407
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks