NIPBL
Information NIPBL
- Description
Plays an important role in the loading of the cohesin complex on to DNA (PubMed:29094699). Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (By similarity). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881). {ECO:0000250|UniProtKB:Q6KC79, ECO:0000269|PubMed:28041881, ECO:0000269|PubMed:29094699}.(Source UnitProtKB).
- Full Name
NIPBL cohesin loading factor
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 11
- Biotypes
- 9
- Peaks
- 315,819
- Non-redundant peaks
- 167,551
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 71175
- Official Gene Name
- Nipbl
- JASPAR
- MGI
- MGI:1913976
- Ensembl
- ENSMUSG00000022141
- UniProt
- Q6KCD5
- Genevisible
- Q6KCD5
- RefSeq
- NM_201232
- Aliases
- 4921518A06Rik; 4933421G18Rik
Datasets Table for NIPBL
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NIPBL | MIN6 | GEO | Mus musculus | GSE101207 | 720 | |||
| NIPBL | MEF | GEO | Mus musculus | GSE76303 | 36,291 | |||
| NIPBL | lymphoma | GEO | Mus musculus | GSE137216 | 11,734 | |||
| NIPBL | thymocyte | GEO | Mus musculus | GSE48763 | 19,972 | |||
| NIPBL | Th17 | GEO | Mus musculus | GSE63778 | 8,854 | |||
| NIPBL | CH12 | GEO | Mus musculus | GSE121355 | 17,757 | |||
| NIPBL | B-cell | activated_HU | GEO | Mus musculus | GSE98119 | 73,591 | ||
| NIPBL | teratocarcinoma | GEO | Mus musculus | GSE132784 | 15,589 | |||
| NIPBL | pro-B-cell | GEO | Mus musculus | GSE130213 | 55,065 | |||
| NIPBL | B-cell | activated | GEO | Mus musculus | GSE98119 | 57,623 | ||
| NIPBL | CH12 | wt | GEO | Mus musculus | GSE121355 | 18,623 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |