NIPBL
Information NIPBL
- Description
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Full Name
NIPBL cohesin loading factor
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 18
- Biotypes
- 10
- Peaks
- 186,021
- Non-redundant peaks
- 106,601
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
Datasets Table for NIPBL
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
NIPBL | A-549 | GEO | Homo sapiens | GSE76893 | 13,301 | |||
NIPBL | WA09 | GEO | Homo sapiens | GSE105028 | 4,084 | |||
NIPBL | WA09 | heat-shock | GEO | Homo sapiens | GSE105028 | 2,056 | ||
NIPBL | HEK293T | WT | GEO | Homo sapiens | GSE122299 | 1,845 | ||
NIPBL | HEK293T | CRISPR | GEO | Homo sapiens | GSE122299 | 1,885 | ||
NIPBL | HEK293T | CRISPR-2 | GEO | Homo sapiens | GSE122299 | 2,745 | ||
NIPBL | MCF-7 | GEO | Homo sapiens | GSE76893 | 6,857 | |||
NIPBL | GM12878 | GEO | Homo sapiens | GSE93080 | 24,979 | |||
NIPBL | GP5D | SIRAD21 | GEO | Homo sapiens | GSE51234 | 4,500 | ||
NIPBL | LCL | GEO | Homo sapiens | GSE38395 | 11,191 | |||
NIPBL | Hep-G2 | GEO | Homo sapiens | GSE76893 | 7,544 | |||
NIPBL | GP5D | GEO | Homo sapiens | GSE51234 | 26,525 | |||
NIPBL | hESC | activin | GEO | Homo sapiens | GSE64758 | 4,367 | ||
NIPBL | hESC | GEO | Homo sapiens | GSE64758 | 3,857 | |||
NIPBL | hESC | WNT3A | GEO | Homo sapiens | GSE64758 | 4,106 | ||
NIPBL | hESC | WNT3A_ACTIVIN | GEO | Homo sapiens | GSE64758 | 7,921 | ||
NIPBL | HCT-116 | RAD21-mAC | GEO | Homo sapiens | GSE104888 | 28,029 | ||
NIPBL | HCT-116 | RAD21-mAC_500uM_auxin | GEO | Homo sapiens | GSE104888 | 30,229 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |