NKX2-1
Information NKX2-1
- Description
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123). {ECO:0000250|UniProtKB:P23441, ECO:0000269|PubMed:22356123, ECO:0000269|PubMed:22955271}.(Source UnitProtKB).
- Full Name
NK2 homeobox 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 3
- Peaks
- 130,622
- Non-redundant peaks
- 76,387
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 21869
- Official Gene Name
- Nkx2-1
- JASPAR
- MGI
- MGI:108067
- Ensembl
- ENSMUSG00000001496
- UniProt
- P50220
- Genevisible
- P50220
- RefSeq
- NM_009385
- Aliases
- AV026640; Nkx2.1; T/EBP; Titf1; Ttf-1; thyroid transcription factor-1; thyroid-specific enhancer-binding protein; tinman
Datasets Table for NKX2-1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NKX2-1 | basal-ganglia | GEO | Mus musculus | GSE85704 | 39,953 | |||
| NKX2-1 | lung | Abcam-76013 | GEO | Mus musculus | GSE129627 | 7,953 | ||
| NKX2-1 | lung | Abcam-133638 | GEO | Mus musculus | GSE129627 | 17,493 | ||
| NKX2-1 | lung | Abcam-133737 | GEO | Mus musculus | GSE129627 | 7,761 | ||
| NKX2-1 | lung | Millipore | GEO | Mus musculus | GSE129627 | 18,813 | ||
| NKX2-1 | lung-adenocarcinoma | GEO | Mus musculus | GSE43252 | 38,649 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |