NKX2-1
Information NKX2-1
- Description
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]
- Full Name
NK2 homeobox 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 4
- Peaks
- 139,640
- Non-redundant peaks
- 124,382
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 7080
- Official Gene Name
- NKX2-1
- JASPAR
- Ensembl
- ENSG00000136352
- UniProt
- P43699
- Genevisible
- P43699
- RefSeq
- NM_001079668
- Aliases
- BCH; BHC; NK-2; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
Datasets Table for NKX2-1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
NKX2-1 | NCI-H2087 | GEO | Homo sapiens | GSE39998 | 13,468 | |||
NKX2-1 | NCI-H1819 | GEO | Homo sapiens | GSE39998 | 11,236 | |||
NKX2-1 | NCI-H3122 | GEO | Homo sapiens | GSE39998 | 61,517 | |||
NKX2-1 | H9 | derived-cIN | GEO | Homo sapiens | GSE99937 | 53,419 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |