NKX2-1

Information NKX2-1

Description

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

Full Name

NK2 homeobox 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
4
Peaks
139,640
Non-redundant peaks
124,382

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
7080
Official Gene Name
NKX2-1
JASPAR
Ensembl
ENSG00000136352
UniProt
P43699
Genevisible
P43699
RefSeq
NM_001079668
Aliases
BCH; BHC; NK-2; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
All peaks NKX2-1
Download BED file
Non redundant peaks NKX2-1
Download BED file
SEQUENCES NKX2-1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for NKX2-1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NKX2-1 NCI-H2087 GEO Homo sapiens GSE39998 13,468
NKX2-1 NCI-H1819 GEO Homo sapiens GSE39998 11,236
NKX2-1 NCI-H3122 GEO Homo sapiens GSE39998 61,517
NKX2-1 H9 derived-cIN GEO Homo sapiens GSE99937 53,419
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks