NKX2-5
Information NKX2-5
- Description
Transcription factor required for the development of the heart and the spleen (PubMed:9584153, PubMed:19483677, PubMed:22560297). During heart development, acts as a transcriptional activator of ANF in cooperation with GATA4 (PubMed:9584153). Binds to the core DNA motif of NPPA promoter (PubMed:19483677). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). {ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:9584153}.(Source UnitProtKB).
- Full Name
NK2 homeobox 5
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 40,324
- Non-redundant peaks
- 37,534
TF Classification
- Familly
- Homeo domain factors
- Sub Familly
- NK-related factors
Source JASPAR
Datasets Table for NKX2-5
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NKX2-5 | heart | GEO | Mus musculus | GSE35151 | 6,219 | |||
| NKX2-5 | heart | GEO | Mus musculus | GSE44574 | 6,226 | |||
| NKX2-5 | HL-1 | GEO | Mus musculus | GSE21529 | 27,879 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |