NKX3-1
Information NKX3-1
- Description
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland. {ECO:0000250, ECO:0000269|PubMed:12036903}.(Source UnitProtKB).
- Full Name
NK3 homeobox 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 74,549
- Non-redundant peaks
- 73,134
TF Classification
- Familly
- Homeo domain factors
- Sub Familly
- NK-related factors
Source JASPAR
Datasets Table for NKX3-1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NKX3-1 | prostate | GEO | Mus musculus | GSE35971 | 72,223 | |||
| NKX3-1 | prostate | KO | GEO | Mus musculus | GSE35971 | 2,326 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |