NOTCH1

Information NOTCH1

Description

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]

Full Name

notch receptor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
17
Biotypes
10
Peaks
110,645
Non-redundant peaks
82,418

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
4851
Official Gene Name
NOTCH1
JASPAR
Ensembl
ENSG00000148400
UniProt
P46531
Genevisible
P46531
RefSeq
NM_017617
Aliases
AOS5; AOVD1; TAN1; hN1
All peaks NOTCH1
Download BED file
Non redundant peaks NOTCH1
Download BED file
SEQUENCES NOTCH1
Download FASTA file
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Datasets Table for NOTCH1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NOTCH1 GSC8-11 dasatinib GEO Homo sapiens GSE74557 2,481
NOTCH1 GSC8-11 12d-das GEO Homo sapiens GSE74557 453
NOTCH1 SP-49 GEO Homo sapiens GSE97541 282
NOTCH1 CD34 GEO Homo sapiens GSE63010 5,630
NOTCH1 HPBALL GEO Homo sapiens GSE39263 59,212
NOTCH1 REC-1 GEO Homo sapiens GSE97541 1,304
NOTCH1 NICD REC-1 GSI-mock-washout GEO Homo sapiens GSE97541 117
NOTCH1 NICD REC-1 GSI-washout GEO Homo sapiens GSE97541 2,241
NOTCH1 THP-6 shEts1 GEO Homo sapiens GSE138516 1,283
NOTCH1 THP-6 shCtrl GEO Homo sapiens GSE138516 1,802
NOTCH1 CUTLL1 GEO Homo sapiens GSE29600 19,969
NOTCH1 MDA-MB-157 GSI GEO Homo sapiens GSE116868 736
NOTCH1 MDA-MB-157 GEO Homo sapiens GSE116868 2,180
NOTCH1 HCC1599 GSI GEO Homo sapiens GSE116871 2,951
NOTCH1 HCC1599 GEO Homo sapiens GSE116871 6,736
NOTCH1 pulmonary-artery endothelial-cell_siCtrl GEO Homo sapiens GSE89786 1,845
NOTCH1 pulmonary-artery endothelial-cell_siPFKFB3 GEO Homo sapiens GSE89786 1,423
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks