NR1H2-3
Information NR1H2-3
- Description
Targets NR1H2 and 3. Oxysterols receptor LXR-beta. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281, PubMed:24206663, PubMed:28846071). (Source UniProtKB)
- Full Name
NR1H2-3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 1
- Peaks
- 150,835
- Non-redundant peaks
- 72,563
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for NR1H2-3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NR1H2-3 | macrophage | KLA6h | GEO | Mus musculus | GSE79423 | 32,653 | ||
| NR1H2-3 | macrophage | KLA24h | GEO | Mus musculus | GSE79423 | 10,154 | ||
| NR1H2-3 | macrophage | GEO | Mus musculus | GSE79423 | 29,688 | |||
| NR1H2-3 | macrophage | KLA1h | GEO | Mus musculus | GSE79423 | 35,175 | ||
| NR1H2-3 | macrophage | GW3965 | GEO | Mus musculus | GSE79423 | 43,165 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |