NR1H3

Information NR1H3

Description

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Full Name

nuclear receptor subfamily 1 group H member 3

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
1,900
Non-redundant peaks
1,798

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
10062
Official Gene Name
NR1H3
JASPAR
Ensembl
ENSG00000025434
UniProt
Q13133
Genevisible
Q13133
RefSeq
NM_001130101
Aliases
LXR-a; LXRA; LXRa; RLD-1
All peaks NR1H3
Download BED file
Non redundant peaks NR1H3
Download BED file
SEQUENCES NR1H3
Download FASTA file
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Datasets Table for NR1H3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NR1H3 SGBS GEO Homo sapiens GSE41629 1,254
NR1H3 THP-1 GEO Homo sapiens GSE28319 330
NR1H3 THP-1 T09 GEO Homo sapiens GSE28319 316
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks