NR3C1
Information NR3C1
- Description
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:15037546}.; [Isoform 1]: Has transcriptional activation and repression activity (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:21994940, ECO:0000269|PubMed:25847991}.; [Isoform 3]: Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity). Loses this transcription modulator function on its own (By similarity). Has no hormone-binding activity (PubMed:20660300). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity). Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:20660300}.
- Full Name
nuclear receptor subfamily 3, group C, member 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 84
- Biotypes
- 13
- Peaks
- 1,710,600
- Non-redundant peaks
- 388,660
TF Classification
- Familly
- Nuclear receptors with C4 zinc fingers
- Sub Familly
- Steroid hormone receptors (NR3)
Source JASPAR
Datasets Table for NR3C1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
NR3C1 | mammary-cell | Afos_Dex-E2 | GEO | Mus musculus | GSE46123 | 17,481 | ||
NR3C1 | mammary-cell | GEO | Mus musculus | GSE46123 | 3,949 | |||
NR3C1 | mammary-cell | Afos_Dex | GEO | Mus musculus | GSE46123 | 24,942 | ||
NR3C1 | liver | fed | GEO | Mus musculus | GSE72084 | 9,707 | ||
NR3C1 | liver | ZT0 | GEO | Mus musculus | GSE108689 | 3,404 | ||
NR3C1 | liver | control-diet_pt | GEO | Mus musculus | GSE137978 | 35,756 | ||
NR3C1 | liver | ZT8 | GEO | Mus musculus | GSE108689 | 8,305 | ||
NR3C1 | liver | High-Fat-diet_pt | GEO | Mus musculus | GSE137978 | 8,980 | ||
NR3C1 | liver | ZT16 | GEO | Mus musculus | GSE108689 | 111 | ||
NR3C1 | liver | ZT12 | GEO | Mus musculus | GSE108689 | 5,278 | ||
NR3C1 | liver | KO | GEO | Mus musculus | GSE108689 | 8,632 | ||
NR3C1 | liver | GEO | Mus musculus | GSE45674 | 32,175 | |||
NR3C1 | liver | control-diet_sc | GEO | Mus musculus | GSE137978 | 35,756 | ||
NR3C1 | MEF | Klf15-KO_dex | GEO | Mus musculus | GSE69947 | 26,494 | ||
NR3C1 | MEF | GEO | Mus musculus | GSE126654 | 23,278 | |||
NR3C1 | MEF | dex | GEO | Mus musculus | GSE69947 | 22,353 | ||
NR3C1 | MEF | Nr3c1-KO | GEO | Mus musculus | GSE126654 | 662 | ||
NR3C1 | MEF | veh | GEO | Mus musculus | GSE69947 | 5,025 | ||
NR3C1 | MEF | DEX | GEO | Mus musculus | GSE108634 | 13,009 | ||
NR3C1 | MEF | mut | GEO | Mus musculus | GSE126654 | 6,135 | ||
NR3C1 | MEF | DEX_WT | GEO | Mus musculus | GSE108634 | 19,162 | ||
NR3C1 | MEF | KO | GEO | Mus musculus | GSE126654 | 662 | ||
NR3C1 | hepatoma | TNF | GEO | Mus musculus | GSE123953 | 655 | ||
NR3C1 | hepatoma | Dex_TNF | GEO | Mus musculus | GSE123953 | 4,871 | ||
NR3C1 | primary-hepatocyte | corticosterone | GEO | Mus musculus | GSE72084 | 10,965 | ||
NR3C1 | kidney | GEO | Mus musculus | GSE115368 | 16,829 | |||
NR3C1 | kidney | E12-Ramp3 | GEO | Mus musculus | GSE115368 | 42,441 | ||
NR3C1 | adenocarcinoma | WT_DEX | GEO | Mus musculus | GSE108634 | 302 | ||
NR3C1 | adenocarcinoma | GFP_DEX | GEO | Mus musculus | GSE108634 | 3,559 | ||
NR3C1 | adenocarcinoma | tetra_DEX | GEO | Mus musculus | GSE108634 | 13,435 | ||
NR3C1 | mammary-epithelium | 12h | GEO | Mus musculus | GSE132502 | 8,636 | ||
NR3C1 | brown-preadipocyte | vec-2-4h | GEO | Mus musculus | GSE76619 | 2,426 | ||
NR3C1 | brown-preadipocyte | vec-0h | GEO | Mus musculus | GSE76619 | 1,904 | ||
NR3C1 | mammary-gland | L1_delE1 | GEO | Mus musculus | GSE115368 | 333,197 | ||
NR3C1 | mammary-gland | L1_delE3 | GEO | Mus musculus | GSE115368 | 40,428 | ||
NR3C1 | mammary-gland | L1 | GEO | Mus musculus | GSE74826 | 23,341 | ||
NR3C1 | mammary-gland | L1_Wap-delE1a | GEO | Mus musculus | GSE74826 | 36,913 | ||
NR3C1 | mammary-gland | L1_Wap-delE1b | GEO | Mus musculus | GSE74826 | 69,845 | ||
NR3C1 | mammary-gland | L1_Wap-delE1c | GEO | Mus musculus | GSE74826 | 3,984 | ||
NR3C1 | mammary-gland | L1 | GEO | Mus musculus | GSE84115 | 41,601 | ||
NR3C1 | mammary-gland | L1_Wap-delE1a-E2 | GEO | Mus musculus | GSE74826 | 78,212 | ||
NR3C1 | mammary-gland | I12 | GEO | Mus musculus | GSE84115 | 48,410 | ||
NR3C1 | mammary-gland | P13 | GEO | Mus musculus | GSE82275 | 17,632 | ||
NR3C1 | mammary-gland | L1_delE3-delE2 | GEO | Mus musculus | GSE115368 | 44,359 | ||
NR3C1 | mammary-gland | delA | GEO | Mus musculus | GSE92591 | 24,663 | ||
NR3C1 | mammary-gland | delC | GEO | Mus musculus | GSE92591 | 16,181 | ||
NR3C1 | mammary-gland | L1_Wap-delE3 | GEO | Mus musculus | GSE74826 | 17,764 | ||
NR3C1 | mammary-gland | L1_Wap-delE2 | GEO | Mus musculus | GSE74826 | 10,403 | ||
NR3C1 | mammary-gland | L10_delE3 | GEO | Mus musculus | GSE115368 | 34,568 | ||
NR3C1 | mammary-gland | L1 | GEO | Mus musculus | GSE115368 | 76,231 | ||
NR3C1 | mammary-gland | L10_delE3-delE2 | GEO | Mus musculus | GSE115368 | 62,887 | ||
NR3C1 | AtT-20 | Pax7 | GEO | Mus musculus | GSE87180 | 15,057 | ||
NR3C1 | AtT-20 | GEO | Mus musculus | GSE87180 | 38,596 | |||
NR3C1 | AtT-20 | LIF | GEO | Mus musculus | GSE37235 | 1,745 | ||
NR3C1 | BMDM | Dex | GEO | Mus musculus | GSE99887 | 9,607 | ||
NR3C1 | BMDM | GEO | Mus musculus | GSE109131 | 520 | |||
NR3C1 | BMDM | LPS-DEX | GEO | Mus musculus | GSE109131 | 23,186 | ||
NR3C1 | BMDM | Dex | GEO | Mus musculus | GSE31796 | 7,441 | ||
NR3C1 | BMDM | Dex | GEO | Mus musculus | GSE61877 | 178 | ||
NR3C1 | hepatoma | Dex | GEO | Mus musculus | GSE123953 | 4,029 | ||
NR3C1 | hepatoma | GEO | Mus musculus | GSE123953 | 178 | |||
NR3C1 | mammary-epithelium | 1h | GEO | Mus musculus | GSE132502 | 15,862 | ||
NR3C1 | brown-preadipocyte | cre-0h | GEO | Mus musculus | GSE76619 | 920 | ||
NR3C1 | brown-preadipocyte | vec-4h | GEO | Mus musculus | GSE76619 | 7,080 | ||
NR3C1 | mammary-gland | L1_Wap-delE1a-E2-3 | GEO | Mus musculus | GSE74826 | 49,446 | ||
NR3C1 | mammary-gland | I24 | GEO | Mus musculus | GSE84115 | 24,988 | ||
NR3C1 | mammary-cell | Dex | GEO | Mus musculus | GSE46123 | 45,379 | ||
NR3C1 | mammary-cell | E2 | GEO | Mus musculus | GSE46123 | 38,631 | ||
NR3C1 | mammary-cell | Dex-E2 | GEO | Mus musculus | GSE46123 | 19,586 | ||
NR3C1 | BMDM | Dex-FA | GEO | Mus musculus | GSE93736 | 7,018 | ||
NR3C1 | BMDM | DEX | GEO | Mus musculus | GSE109131 | 11,912 | ||
NR3C1 | BMDM | Dex_LPS | GEO | Mus musculus | GSE31796 | 8,695 | ||
NR3C1 | BMDM | LPS-Dex-FA | GEO | Mus musculus | GSE93736 | 31,412 | ||
NR3C1 | MEF | DEX_sc | GEO | Mus musculus | GSE108634 | 22,563 | ||
NR3C1 | MEF | tetra | GEO | Mus musculus | GSE108634 | 18,878 | ||
NR3C1 | MEF | DEX_tetra | GEO | Mus musculus | GSE108634 | 31,915 | ||
NR3C1 | liver | GEO | Mus musculus | GSE111526 | 19,613 | |||
NR3C1 | liver | High-Fat-diet_sc | GEO | Mus musculus | GSE137978 | 36,653 | ||
NR3C1 | liver | ZT20 | GEO | Mus musculus | GSE108689 | 2,905 | ||
NR3C1 | liver | High-Fat-diet_13wk | GEO | Mus musculus | GSE137978 | 18,656 | ||
NR3C1 | liver | control-diet_13wk | GEO | Mus musculus | GSE137978 | 21,967 | ||
NR3C1 | liver | fasted-24h | GEO | Mus musculus | GSE72084 | 16,360 | ||
NR3C1 | 3T3-L1 | 6h | GEO | Mus musculus | GSE21898 | 5,036 | ||
NR3C1 | AtT-20 | Dex_LIF | GEO | Mus musculus | GSE37235 | 2,335 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |