NR3C1

Information NR3C1

Description

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:15037546}.; [Isoform 1]: Has transcriptional activation and repression activity (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:21994940, ECO:0000269|PubMed:25847991}.; [Isoform 3]: Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity). Loses this transcription modulator function on its own (By similarity). Has no hormone-binding activity (PubMed:20660300). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity). Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:20660300}.

Full Name

nuclear receptor subfamily 3, group C, member 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
84
Biotypes
13
Peaks
1,710,600
Non-redundant peaks
388,660

TF Classification

Familly
Nuclear receptors with C4 zinc fingers
Sub Familly
Steroid hormone receptors (NR3)

Source JASPAR

External IDs

NCBI Gene
14815
Official Gene Name
Nr3c1
JASPAR
MA0113.2
MGI
MGI:95824
Ensembl
ENSMUSG00000024431
UniProt
P06537
Genevisible
P06537
RefSeq
NM_008173
Aliases
GR; Grl-1; Grl1; glucocorticoid receptor
All peaks NR3C1
Download BED file
Non redundant peaks NR3C1
Download BED file
SEQUENCES NR3C1
Download FASTA file
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Datasets Table for NR3C1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NR3C1 mammary-cell Afos_Dex-E2 GEO Mus musculus GSE46123 17,481
NR3C1 mammary-cell GEO Mus musculus GSE46123 3,949
NR3C1 mammary-cell Afos_Dex GEO Mus musculus GSE46123 24,942
NR3C1 liver fed GEO Mus musculus GSE72084 9,707
NR3C1 liver ZT0 GEO Mus musculus GSE108689 3,404
NR3C1 liver control-diet_pt GEO Mus musculus GSE137978 35,756
NR3C1 liver ZT8 GEO Mus musculus GSE108689 8,305
NR3C1 liver High-Fat-diet_pt GEO Mus musculus GSE137978 8,980
NR3C1 liver ZT16 GEO Mus musculus GSE108689 111
NR3C1 liver ZT12 GEO Mus musculus GSE108689 5,278
NR3C1 liver KO GEO Mus musculus GSE108689 8,632
NR3C1 liver GEO Mus musculus GSE45674 32,175
NR3C1 liver control-diet_sc GEO Mus musculus GSE137978 35,756
NR3C1 MEF Klf15-KO_dex GEO Mus musculus GSE69947 26,494
NR3C1 MEF GEO Mus musculus GSE126654 23,278
NR3C1 MEF dex GEO Mus musculus GSE69947 22,353
NR3C1 MEF Nr3c1-KO GEO Mus musculus GSE126654 662
NR3C1 MEF veh GEO Mus musculus GSE69947 5,025
NR3C1 MEF DEX GEO Mus musculus GSE108634 13,009
NR3C1 MEF mut GEO Mus musculus GSE126654 6,135
NR3C1 MEF DEX_WT GEO Mus musculus GSE108634 19,162
NR3C1 MEF KO GEO Mus musculus GSE126654 662
NR3C1 hepatoma TNF GEO Mus musculus GSE123953 655
NR3C1 hepatoma Dex_TNF GEO Mus musculus GSE123953 4,871
NR3C1 primary-hepatocyte corticosterone GEO Mus musculus GSE72084 10,965
NR3C1 kidney GEO Mus musculus GSE115368 16,829
NR3C1 kidney E12-Ramp3 GEO Mus musculus GSE115368 42,441
NR3C1 adenocarcinoma WT_DEX GEO Mus musculus GSE108634 302
NR3C1 adenocarcinoma GFP_DEX GEO Mus musculus GSE108634 3,559
NR3C1 adenocarcinoma tetra_DEX GEO Mus musculus GSE108634 13,435
NR3C1 mammary-epithelium 12h GEO Mus musculus GSE132502 8,636
NR3C1 brown-preadipocyte vec-2-4h GEO Mus musculus GSE76619 2,426
NR3C1 brown-preadipocyte vec-0h GEO Mus musculus GSE76619 1,904
NR3C1 mammary-gland L1_delE1 GEO Mus musculus GSE115368 333,197
NR3C1 mammary-gland L1_delE3 GEO Mus musculus GSE115368 40,428
NR3C1 mammary-gland L1 GEO Mus musculus GSE74826 23,341
NR3C1 mammary-gland L1_Wap-delE1a GEO Mus musculus GSE74826 36,913
NR3C1 mammary-gland L1_Wap-delE1b GEO Mus musculus GSE74826 69,845
NR3C1 mammary-gland L1_Wap-delE1c GEO Mus musculus GSE74826 3,984
NR3C1 mammary-gland L1 GEO Mus musculus GSE84115 41,601
NR3C1 mammary-gland L1_Wap-delE1a-E2 GEO Mus musculus GSE74826 78,212
NR3C1 mammary-gland I12 GEO Mus musculus GSE84115 48,410
NR3C1 mammary-gland P13 GEO Mus musculus GSE82275 17,632
NR3C1 mammary-gland L1_delE3-delE2 GEO Mus musculus GSE115368 44,359
NR3C1 mammary-gland delA GEO Mus musculus GSE92591 24,663
NR3C1 mammary-gland delC GEO Mus musculus GSE92591 16,181
NR3C1 mammary-gland L1_Wap-delE3 GEO Mus musculus GSE74826 17,764
NR3C1 mammary-gland L1_Wap-delE2 GEO Mus musculus GSE74826 10,403
NR3C1 mammary-gland L10_delE3 GEO Mus musculus GSE115368 34,568
NR3C1 mammary-gland L1 GEO Mus musculus GSE115368 76,231
NR3C1 mammary-gland L10_delE3-delE2 GEO Mus musculus GSE115368 62,887
NR3C1 AtT-20 Pax7 GEO Mus musculus GSE87180 15,057
NR3C1 AtT-20 GEO Mus musculus GSE87180 38,596
NR3C1 AtT-20 LIF GEO Mus musculus GSE37235 1,745
NR3C1 BMDM Dex GEO Mus musculus GSE99887 9,607
NR3C1 BMDM GEO Mus musculus GSE109131 520
NR3C1 BMDM LPS-DEX GEO Mus musculus GSE109131 23,186
NR3C1 BMDM Dex GEO Mus musculus GSE31796 7,441
NR3C1 BMDM Dex GEO Mus musculus GSE61877 178
NR3C1 hepatoma Dex GEO Mus musculus GSE123953 4,029
NR3C1 hepatoma GEO Mus musculus GSE123953 178
NR3C1 mammary-epithelium 1h GEO Mus musculus GSE132502 15,862
NR3C1 brown-preadipocyte cre-0h GEO Mus musculus GSE76619 920
NR3C1 brown-preadipocyte vec-4h GEO Mus musculus GSE76619 7,080
NR3C1 mammary-gland L1_Wap-delE1a-E2-3 GEO Mus musculus GSE74826 49,446
NR3C1 mammary-gland I24 GEO Mus musculus GSE84115 24,988
NR3C1 mammary-cell Dex GEO Mus musculus GSE46123 45,379
NR3C1 mammary-cell E2 GEO Mus musculus GSE46123 38,631
NR3C1 mammary-cell Dex-E2 GEO Mus musculus GSE46123 19,586
NR3C1 BMDM Dex-FA GEO Mus musculus GSE93736 7,018
NR3C1 BMDM DEX GEO Mus musculus GSE109131 11,912
NR3C1 BMDM Dex_LPS GEO Mus musculus GSE31796 8,695
NR3C1 BMDM LPS-Dex-FA GEO Mus musculus GSE93736 31,412
NR3C1 MEF DEX_sc GEO Mus musculus GSE108634 22,563
NR3C1 MEF tetra GEO Mus musculus GSE108634 18,878
NR3C1 MEF DEX_tetra GEO Mus musculus GSE108634 31,915
NR3C1 liver GEO Mus musculus GSE111526 19,613
NR3C1 liver High-Fat-diet_sc GEO Mus musculus GSE137978 36,653
NR3C1 liver ZT20 GEO Mus musculus GSE108689 2,905
NR3C1 liver High-Fat-diet_13wk GEO Mus musculus GSE137978 18,656
NR3C1 liver control-diet_13wk GEO Mus musculus GSE137978 21,967
NR3C1 liver fasted-24h GEO Mus musculus GSE72084 16,360
NR3C1 3T3-L1 6h GEO Mus musculus GSE21898 5,036
NR3C1 AtT-20 Dex_LIF GEO Mus musculus GSE37235 2,335
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks