NR5A2
Information NR5A2
- Description
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). {ECO:0000250|UniProtKB:O00482, ECO:0000269|PubMed:30555544}.(Source UnitProtKB).
- Full Name
nuclear receptor subfamily 5, group A, member 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 83,732
- Non-redundant peaks
- 76,779
TF Classification
- Familly
- Nuclear receptors with C4 zinc fingers
- Sub Familly
- FTZ-F1-related receptors (NR5)
Source JASPAR
External IDs
- NCBI Gene
- 26424
- Official Gene Name
- Nr5a2
- JASPAR
- MA0505.1
- MGI
- MGI:1346834
- Ensembl
- ENSMUSG00000026398
- UniProt
- P45448
- Genevisible
- P45448
- RefSeq
- NM_030676
- Aliases
- AU020803; D1Ertd308e; Ftf; LRH-1; UF2-H3B
Datasets Table for NR5A2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NR5A2 | pancreas | GEO | Mus musculus | GSE34295 | 22,606 | |||
| NR5A2 | mESC | GEO | Mus musculus | GSE19019 | 3,349 | |||
| NR5A2 | mESC | serum | GEO | Mus musculus | GSE92407 | 57,777 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |