OGG1

Information OGG1

Description

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Full Name

8-oxoguanine DNA glycosylase

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
1
Peaks
149,838
Non-redundant peaks
76,575

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
4968
Official Gene Name
OGG1
JASPAR
Ensembl
ENSG00000114026
UniProt
O15527
Genevisible
O15527
RefSeq
NM_001354648
Aliases
HMMH; HOGG1; MUTM; OGH1
All peaks OGG1
Download BED file
Non redundant peaks OGG1
Download BED file
SEQUENCES OGG1
Download FASTA file
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Datasets Table for OGG1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
OGG1 HEK293 GEO Homo sapiens GSE89017 62,568
OGG1 HEK293 30_min GEO Homo sapiens GSE89017 15,377
OGG1 HEK293 60_min GEO Homo sapiens GSE89017 32,170
OGG1 HEK293 15min GEO Homo sapiens GSE89017 39,723
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks