OGG1
Information OGG1
- Description
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
- Full Name
8-oxoguanine DNA glycosylase
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 1
- Peaks
- 149,838
- Non-redundant peaks
- 76,575
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 4968
- Official Gene Name
- OGG1
- JASPAR
- Ensembl
- ENSG00000114026
- UniProt
- O15527
- Genevisible
- O15527
- RefSeq
- NM_001354648
- Aliases
- HMMH; HOGG1; MUTM; OGH1
Datasets Table for OGG1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
OGG1 | HEK293 | GEO | Homo sapiens | GSE89017 | 62,568 | |||
OGG1 | HEK293 | 30_min | GEO | Homo sapiens | GSE89017 | 15,377 | ||
OGG1 | HEK293 | 60_min | GEO | Homo sapiens | GSE89017 | 32,170 | ||
OGG1 | HEK293 | 15min | GEO | Homo sapiens | GSE89017 | 39,723 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |