PAX5

Information PAX5

Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Full Name

paired box 5

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
9
Biotypes
7
Peaks
347,026
Non-redundant peaks
210,607

TF Classification

Super Class
Helix-turn-helix domains
Class
Paired box factors
Familly
Paired domain only
Sub Familly
PAX-2-like factors (partial homeobox)

Source TFClass

External IDs

NCBI Gene
5079
Official Gene Name
PAX5
JASPAR
MA0014
Ensembl
ENSG00000196092
UniProt
Q02548
Genevisible
Q02548
RefSeq
NM_001280547
Aliases
ALL3; BSAP
All peaks PAX5
Download BED file
Non redundant peaks PAX5
Download BED file
SEQUENCES PAX5
Download FASTA file
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Datasets Table for PAX5

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PAX5 OCI-Ly7 GEO Homo sapiens GSE69558 6,538
PAX5 fetal testis GEO Homo sapiens GSE100639 75,905
PAX5 GM12892 ENCODE Homo sapiens ENCSR000BJI 30,331
PAX5 GM12891 ENCODE Homo sapiens ENCSR000BJH 21,245
PAX5 GM12878 ENCODE Homo sapiens ENCSR000BHD 71,092
PAX5 GM12878 ENCODE Homo sapiens ENCSR000BHJ 65,459
PAX5 NALM-6 GEO Homo sapiens GSE115764 19,981
PAX5 NALM-6 GEO Homo sapiens GSE126300 55,150
PAX5 DOHH2 GEO Homo sapiens GSE69558 1,325
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks