PCBP1

Information PCBP1

Description

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

Full Name

poly(rC) binding protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
2
Peaks
123,546
Non-redundant peaks
65,075

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
5093
Official Gene Name
PCBP1
JASPAR
Ensembl
ENSG00000169564
UniProt
Q15365
Genevisible
Q15365
RefSeq
NM_006196
Aliases
HEL-S-85; HNRPE1; HNRPX; hnRNP-E1; hnRNP-X
All peaks PCBP1
Download BED file
Non redundant peaks PCBP1
Download BED file
SEQUENCES PCBP1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for PCBP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PCBP1 Hep-G2 GEO Homo sapiens GSE120104 51,371
PCBP1 K-562 GEO Homo sapiens GSE120104 21,178
PCBP1 K-562 ENCODE Homo sapiens ENCSR052PTN 19,411
PCBP1 Hep-G2 ENCODE Homo sapiens ENCSR872EVQ 31,586
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks