PCBP2

Information PCBP2

Description

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]

Full Name

poly(rC) binding protein 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
2
Peaks
51,171
Non-redundant peaks
29,905

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
5094
Official Gene Name
PCBP2
JASPAR
Ensembl
ENSG00000197111
UniProt
Q15366
Genevisible
Q15366
RefSeq
NM_001098620
Aliases
HNRNPE2; HNRPE2; hnRNP-E2
All peaks PCBP2
Download BED file
Non redundant peaks PCBP2
Download BED file
SEQUENCES PCBP2
Download FASTA file
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Datasets Table for PCBP2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PCBP2 Hep-G2 GEO Homo sapiens GSE120104 22,333
PCBP2 K-562 GEO Homo sapiens GSE120104 4,935
PCBP2 K-562 ENCODE Homo sapiens ENCSR603REQ 2,946
PCBP2 Hep-G2 ENCODE Homo sapiens ENCSR945NSF 20,957
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks