PCBP2
Information PCBP2
- Description
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
- Full Name
poly(rC) binding protein 2
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 2
- Peaks
- 51,171
- Non-redundant peaks
- 29,905
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 5094
- Official Gene Name
- PCBP2
- JASPAR
- Ensembl
- ENSG00000197111
- UniProt
- Q15366
- Genevisible
- Q15366
- RefSeq
- NM_001098620
- Aliases
- HNRNPE2; HNRPE2; hnRNP-E2
Datasets Table for PCBP2
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
PCBP2 | Hep-G2 | GEO | Homo sapiens | GSE120104 | 22,333 | |||
PCBP2 | K-562 | GEO | Homo sapiens | GSE120104 | 4,935 | |||
PCBP2 | K-562 | ENCODE | Homo sapiens | ENCSR603REQ | 2,946 | |||
PCBP2 | Hep-G2 | ENCODE | Homo sapiens | ENCSR945NSF | 20,957 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |