PCGF2

Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456). Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). {ECO:0000250|UniProtKB:P35227, ECO:0000269|PubMed:11750047, ECO:0000269|PubMed:15183898, ECO:0000269|PubMed:15728456, ECO:0000269|PubMed:8521824, ECO:0000269|PubMed:8625838, ECO:0000305}.(Source UnitProtKB).

polycomb group ring finger 2

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10