PCGF2

Information PCGF2

Description

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

Full Name

polycomb group ring finger 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
3
Peaks
15,212
Non-redundant peaks
12,644

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
7703
Official Gene Name
PCGF2
JASPAR
Ensembl
ENSG00000278644
UniProt
P35227
Genevisible
P35227
RefSeq
NM_001369614
Aliases
MEL-18; RNF110; TPFS; ZNF144
All peaks PCGF2
Download BED file
Non redundant peaks PCGF2
Download BED file
SEQUENCES PCGF2
Download FASTA file
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Datasets Table for PCGF2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PCGF2 HEK293T PCGF2fl GEO Homo sapiens GSE119618 1,695
PCGF2 NT2-D1 GEO Homo sapiens GSE101538 3,197
PCGF2 fibroblast MET GEO Homo sapiens GSE55605 6,646
PCGF2 fibroblast OHT GEO Homo sapiens GSE55605 3,674
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks