PCGF3
Information PCGF3
- Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). {ECO:0000250|UniProtKB:Q3KNV8, ECO:0000269|PubMed:28596365}.(Source UnitProtKB).
- Full Name
polycomb group ring finger 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 7,523
- Non-redundant peaks
- 7,446
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 69587
- Official Gene Name
- Pcgf3
- JASPAR
- MGI
- MGI:1916837
- Ensembl
- ENSMUSG00000033623
- UniProt
- Q8BTQ0
- Genevisible
- Q8BTQ0
- RefSeq
- NM_172716
- Aliases
- 2310035N15Rik; D630042K08Rik; DONG1; RNF3A; Rnf3
Datasets Table for PCGF3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PCGF3 | mESC-E14 | RING1-RNF2-KO | GEO | Mus musculus | GSE122715 | 119 | ||
| PCGF3 | mESC-E14 | PCGF1-KO | GEO | Mus musculus | GSE122715 | 7,404 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |