PCGF6
Information PCGF6
- Description
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. {ECO:0000250|UniProtKB:Q9BYE7}.(Source UnitProtKB).
- Full Name
polycomb group ring finger 6
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 14
- Biotypes
- 2
- Peaks
- 123,794
- Non-redundant peaks
- 46,308
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 71041
- Official Gene Name
- Pcgf6
- JASPAR
- MGI
- MGI:1918291
- Ensembl
- ENSMUSG00000025050
- UniProt
- Q99NA9
- Genevisible
- Q99NA9
- RefSeq
- NM_027654
- Aliases
- 4933407A11Rik; MBLR; Mel18 and Bmi1-like RING finger protein; Rnf134
Datasets Table for PCGF6
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PCGF6 | mESC | GEO | Mus musculus | GSE132752 | 16,503 | |||
| PCGF6 | mESC | OHT | GEO | Mus musculus | GSE134053 | 8,594 | ||
| PCGF6 | mESC | I53SOHT | GEO | Mus musculus | GSE134053 | 2,087 | ||
| PCGF6 | mESC | PARETA-OHT | GEO | Mus musculus | GSE134053 | 4,753 | ||
| PCGF6 | mESC | PARETA | GEO | Mus musculus | GSE134053 | 9,206 | ||
| PCGF6 | mESC-E14 | PCGF1-KO | GEO | Mus musculus | GSE122715 | 10,216 | ||
| PCGF6 | mESC-E14 | PCGF6-KO | GEO | Mus musculus | GSE122715 | 5,467 | ||
| PCGF6 | mESC-E14 | PCGF2-4-KO | GEO | Mus musculus | GSE122715 | 23,593 | ||
| PCGF6 | mESC-E14 | shMGA | GEO | Mus musculus | GSE122715 | 1,231 | ||
| PCGF6 | mESC-E14 | RING1-RNF2-KO | GEO | Mus musculus | GSE122715 | 2,213 | ||
| PCGF6 | mESC-E14 | shMGAdHLH | GEO | Mus musculus | GSE122715 | 1,024 | ||
| PCGF6 | mESC-E14 | shCtR | GEO | Mus musculus | GSE122715 | 22,466 | ||
| PCGF6 | mESC-E14 | RING1-KO | GEO | Mus musculus | GSE122715 | 2,826 | ||
| PCGF6 | mESC | TAM | GEO | Mus musculus | GSE132752 | 13,615 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |