PDX1
Information PDX1
- Description
Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'. {ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:9710595}.(Source UnitProtKB).
- Full Name
pancreatic and duodenal homeobox 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 13,438
- Non-redundant peaks
- 13,377
TF Classification
- Familly
- Homeo domain factors
- Sub Familly
- HOX-related factors
Source JASPAR
External IDs
- NCBI Gene
- 18609
- Official Gene Name
- Pdx1
- JASPAR
- MA0132.1
- MGI
- MGI:102851
- Ensembl
- ENSMUSG00000029644
- UniProt
- P52946
- Genevisible
- P52946
- RefSeq
- NM_008814
- Aliases
- IDX-1; IPF-1; Ipf1; Mody4; STF-1; pdx-1
Datasets Table for PDX1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PDX1 | Beta-TC-6 | GEO | Mus musculus | GSE70960 | 13,063 | |||
| PDX1 | NB490 | 43843 | GEO | Mus musculus | GSE91054 | 375 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |