PDX1
Information PDX1
- Description
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]
- Full Name
pancreatic and duodenal homeobox 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 6
- Biotypes
- 5
- Peaks
- 218,108
- Non-redundant peaks
- 138,396
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Homeo domain factors
- Familly
- HOX-related factors
- Sub Familly
- PDX
Source TFClass
Datasets Table for PDX1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PDX1 | islet | ENA | Homo sapiens | ERP001456 | 54,902 | |||
| PDX1 | H9 | ENA | Homo sapiens | ERP004206 | 2,634 | |||
| PDX1 | hESC | GEO | Homo sapiens | GSE58685 | 11,788 | |||
| PDX1 | hiPSC | derived_PPs | GEO | Homo sapiens | GSE106949 | 47,570 | ||
| PDX1 | hiPSC | GEO | Homo sapiens | GSE125768 | 74,777 | |||
| PDX1 | pancreatic-progenitor | GEO | Homo sapiens | GSE117136 | 26,437 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |