PHF19
Information PHF19
- Description
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23104054, PubMed:23160351, PubMed:22438827, PubMed:23273982). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal (PubMed:22438827). Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (By similarity). {ECO:0000250|UniProtKB:Q5T6S3, ECO:0000269|PubMed:22438827, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23273982}.(Source UnitProtKB).
- Full Name
PHD finger protein 19
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 35,969
- Non-redundant peaks
- 31,500
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 74016
- Official Gene Name
- Phf19
- JASPAR
- MGI
- MGI:1921266
- Ensembl
- ENSMUSG00000026873
- UniProt
- Q9CXG9
- Genevisible
- Q9CXG9
- RefSeq
- NM_028716
- Aliases
- 3110009G19Rik; 3321402G02Rik
Datasets Table for PHF19
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PHF19 | mESC | Pcl3-sh7 | GEO | Mus musculus | GSE28325 | 15,084 | ||
| PHF19 | mESC | Pcl3-sh6 | GEO | Mus musculus | GSE28325 | 20,662 | ||
| PHF19 | mESC | GEO | Mus musculus | GSE41589 | 223 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |