PHF8

Information PHF8

Description

Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. {ECO:0000250|UniProtKB:Q9UPP1}.(Source UnitProtKB).

Full Name

PHD finger protein 8

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
8
Biotypes
1
Peaks
316,958
Non-redundant peaks
75,398

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
320595
Official Gene Name
Phf8
JASPAR
MGI
MGI:2444341
Ensembl
ENSMUSG00000041229
UniProt
Q80TJ7
Genevisible
Q80TJ7
RefSeq
Aliases
9830141C09Rik
All peaks PHF8
Download BED file
Non redundant peaks PHF8
Download BED file
SEQUENCES PHF8
Download FASTA file
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Datasets Table for PHF8

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PHF8 prostate high-fat-diet GEO Mus musculus GSE90910 30,981
PHF8 prostate hi-MYC GEO Mus musculus GSE90910 45,626
PHF8 prostate HFD GEO Mus musculus GSE90910 30,981
PHF8 prostate HFD_Hi-MYC GEO Mus musculus GSE90910 46,274
PHF8 prostate GEO Mus musculus GSE90910 35,598
PHF8 prostate control-diet GEO Mus musculus GSE90910 35,598
PHF8 prostate MYC_high-fat-diet GEO Mus musculus GSE90910 46,274
PHF8 prostate MYC_control-diet GEO Mus musculus GSE90910 45,626
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks