PHF8
Information PHF8
- Description
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
- Full Name
PHD finger protein 8
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 6
- Biotypes
- 5
- Peaks
- 130,433
- Non-redundant peaks
- 83,674
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 23133
- Official Gene Name
- PHF8
- JASPAR
- Ensembl
- ENSG00000172943
- UniProt
- Q9UPP1
- Genevisible
- Q9UPP1
- RefSeq
- NM_001184896
- Aliases
- JHDM1F; KDM7B; KIAA1111; MRXSSD; ZNF422
Datasets Table for PHF8
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PHF8 | HeLa | GEO | Homo sapiens | GSE20303 | 2,918 | |||
| PHF8 | HeLa | GEO | Homo sapiens | GSE22478 | 7,464 | |||
| PHF8 | Hep-G2 | ENCODE | Homo sapiens | ENCSR604VAE | 52,928 | |||
| PHF8 | WA01 | ENCODE | Homo sapiens | ENCSR000ATK | 28,000 | |||
| PHF8 | K-562 | ENCODE | Homo sapiens | ENCSR000AQH | 23,427 | |||
| PHF8 | A-549 | ENCODE | Homo sapiens | ENCSR541AOQ | 15,696 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |