PML

Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:10637504, ECO:0000269|PubMed:11907221, ECO:0000269|PubMed:12439746, ECO:0000269|PubMed:14976551, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:16915281, ECO:0000269|PubMed:19136970, ECO:0000269|PubMed:21030605, ECO:0000269|PubMed:21427174, ECO:0000269|PubMed:21779477, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22886304, ECO:0000269|PubMed:23279884, ECO:0000269|PubMed:9488655, ECO:0000269|PubMed:9806545}.(Source UnitProtKB).

promyelocytic leukemia

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10