POU3F2
Information POU3F2
- Description
Transcription factor that plays a key role in neuronal differentiation (PubMed:24243019). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18505825, PubMed:18403418). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (PubMed:24243019). {ECO:0000250|UniProtKB:P56222, ECO:0000269|PubMed:18403418, ECO:0000269|PubMed:18505825, ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220}.(Source UnitProtKB).
- Full Name
POU domain, class 3, transcription factor 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 8
- Biotypes
- 5
- Peaks
- 46,379
- Non-redundant peaks
- 40,192
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 18992
- Official Gene Name
- Pou3f2
- JASPAR
- MGI
- MGI:101895
- Ensembl
- ENSMUSG00000095139
- UniProt
- P31360
- Genevisible
- P31360
- RefSeq
- NM_008899
- Aliases
- 9430075J19Rik; A230098E07Rik; Brn-2; Brn2; OTF-7; Otf7; oct-7
Datasets Table for POU3F2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| POU3F2 | NPC | GEO | Mus musculus | GSE43916 | 3,110 | |||
| POU3F2 | MEF | 48h | GEO | Mus musculus | GSE43916 | 31,450 | ||
| POU3F2 | mESC | Teto-POU3F2 | GEO | Mus musculus | GSE35496 | 4,583 | ||
| POU3F2 | NSC | GEO | Mus musculus | GSE69859 | 1,183 | |||
| POU3F2 | MEF | BAM | GEO | Mus musculus | GSE43916 | 1,264 | ||
| POU3F2 | NPC | GEO | Mus musculus | GSE35496 | 4,789 | |||
| POU3F2 | hiPSC | SGC0946 | GEO | Mus musculus | GSE149017 | 3,753 | ||
| POU3F2 | hiPSC | GEO | Mus musculus | GSE149017 | 7,786 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |