POU5F1

Information POU5F1

Description

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

Full Name

POU class 5 homeobox 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
28
Biotypes
18
Peaks
541,881
Non-redundant peaks
293,387

TF Classification

Super Class
Helix-turn-helix domains
Class
Homeo domain factors
Familly
POU domain factors
Sub Familly
POU5 (Oct-3/4-like factors)

Source TFClass

External IDs

NCBI Gene
5460
Official Gene Name
POU5F1
JASPAR
MA1115
Ensembl
ENSG00000237582
UniProt
Q01860
Genevisible
Q01860
RefSeq
NM_001173531
Aliases
MGC22487; OCT3; OCT4; OTF-3; OTF3; OTF4; Oct-3; Oct-4
All peaks POU5F1
Download BED file
Non redundant peaks POU5F1
Download BED file
SEQUENCES POU5F1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for POU5F1

Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
POU5F1 NCCIT GEO Homo sapiens GSE36134 5,455
POU5F1 NCCIT SNF5 GEO Homo sapiens GSE36134 35,919
POU5F1 WA09 GEO Homo sapiens GSE105028 6,603
POU5F1 WA09 heat-shock GEO Homo sapiens GSE105028 5,241
POU5F1 WA01 3IL ENA Homo sapiens ERP004238 32,313
POU5F1 BJ GEO Homo sapiens GSE36570 769
POU5F1 BJ INDUCED GEO Homo sapiens GSE36570 50,804
POU5F1 BG03 GEO Homo sapiens GSE21614 75,386
POU5F1 SKM-1 GEO Homo sapiens GSE93706 61,011
POU5F1 BJ1-hTERT GEO Homo sapiens GSE92491 19,919
Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
Showing 1 to 10 of 28 entries