POU5F1

Information POU5F1

Description

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

Full Name

POU class 5 homeobox 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
28
Biotypes
18
Peaks
541,881
Non-redundant peaks
293,387

TF Classification

Super Class
Helix-turn-helix domains
Class
Homeo domain factors
Familly
POU domain factors
Sub Familly
POU5 (Oct-3/4-like factors)

Source TFClass

External IDs

NCBI Gene
5460
Official Gene Name
POU5F1
JASPAR
MA1115
Ensembl
ENSG00000237582
UniProt
Q01860
Genevisible
Q01860
RefSeq
NM_001173531
Aliases
MGC22487; OCT3; OCT4; OTF-3; OTF3; OTF4; Oct-3; Oct-4
All peaks POU5F1
Download BED file
Non redundant peaks POU5F1
Download BED file
SEQUENCES POU5F1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for POU5F1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
POU5F1 NCCIT GEO Homo sapiens GSE36134 5,455
POU5F1 NCCIT SNF5 GEO Homo sapiens GSE36134 35,919
POU5F1 WA09 GEO Homo sapiens GSE105028 6,603
POU5F1 WA09 heat-shock GEO Homo sapiens GSE105028 5,241
POU5F1 WA01 3IL ENA Homo sapiens ERP004238 32,313
POU5F1 BJ GEO Homo sapiens GSE36570 769
POU5F1 BJ INDUCED GEO Homo sapiens GSE36570 50,804
POU5F1 BG03 GEO Homo sapiens GSE21614 75,386
POU5F1 SKM-1 GEO Homo sapiens GSE93706 61,011
POU5F1 BJ1-hTERT GEO Homo sapiens GSE92491 19,919
POU5F1 WA01 ENCODE Homo sapiens ENCSR000BMU 4,512
POU5F1 K-562 ENCODE Homo sapiens ENCSR364SNE 5,504
POU5F1 hESC ENCODE Homo sapiens ENCSR264RJX 10,900
POU5F1 H9 GEO Homo sapiens GSE130565 1,067
POU5F1 hESC GEO Homo sapiens GSE20650 268
POU5F1 hESC NAIVE GEO Homo sapiens GSE69646 76,480
POU5F1 hESC GEO Homo sapiens GSE17917 89
POU5F1 hESC PRIMED GEO Homo sapiens GSE69646 28,977
POU5F1 fibroblast foreskin_H GEO Homo sapiens GSE130565 725
POU5F1 hiPSC 3s2 GEO Homo sapiens GSE81899 7,935
POU5F1 hiPSC GEO Homo sapiens GSE56567 31,140
POU5F1 hiPSC GEO Homo sapiens GSE149017 1,602
POU5F1 OSKM GEO Homo sapiens GSE81899 10,366
POU5F1 OSvK GEO Homo sapiens GSE81899 681
POU5F1 OSvKM GEO Homo sapiens GSE81899 1,501
POU5F1 OSK GEO Homo sapiens GSE81899 5,953
POU5F1 neuron bipolar_doxy_4d ENCODE Homo sapiens ENCSR362VCG 3,232
POU5F1 HUES-8 GEO Homo sapiens GSE109524 57,529
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks