PPARA

Information PPARA

Description

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Full Name

peroxisome proliferator activated receptor alpha

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
2,290
Non-redundant peaks
2,290

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
5465
Official Gene Name
PPARA
JASPAR
MA1148
Ensembl
ENSG00000186951
UniProt
Q07869
Genevisible
Q07869
RefSeq
NM_001001928
Aliases
NR1C1; PPAR; PPARalpha; hPPAR
All peaks PPARA
Download BED file
Non redundant peaks PPARA
Download BED file
SEQUENCES PPARA
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for PPARA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PPARA SK-N-SH all-trans-retinoic-acid_6-uM_48-hour ENCODE Homo sapiens ENCSR602QEJ 2,290
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks