PTF1A
Information PTF1A
- Description
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. {ECO:0000269|PubMed:11562365, ECO:0000269|PubMed:12185368, ECO:0000269|PubMed:15543146, ECO:0000269|PubMed:17075007, ECO:0000269|PubMed:9851981}.(Source UnitProtKB).
- Full Name
pancreas specific transcription factor, 1a
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 8
- Biotypes
- 4
- Peaks
- 178,712
- Non-redundant peaks
- 103,511
TF Classification
- Familly
- Basic helix-loop-helix factors (bHLH)
- Sub Familly
- Tal-related factors
Source JASPAR
External IDs
- NCBI Gene
- 19213
- Official Gene Name
- Ptf1a
- JASPAR
- MA1618.1
- MGI
- MGI:1328312
- Ensembl
- ENSMUSG00000026735
- UniProt
- Q9QX98
- Genevisible
- Q9QX98
- RefSeq
- NM_018809
- Aliases
- PTF1-p48; PTF1p48; bHLHa29
Datasets Table for PTF1A
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PTF1A | liver | GEO | Mus musculus | GSE47459 | 19,364 | |||
| PTF1A | pancreas | JEJ | GEO | Mus musculus | GSE86262 | 38,934 | ||
| PTF1A | pancreas | RJM | GEO | Mus musculus | GSE86262 | 36,053 | ||
| PTF1A | pancreas | GEO | Mus musculus | GSE77409 | 17,887 | |||
| PTF1A | pancreas | GEO | Mus musculus | GSE47459 | 17,830 | |||
| PTF1A | telencephalon | GEO | Mus musculus | GSE47459 | 4,635 | |||
| PTF1A | neural-tube | GEO | Mus musculus | GSE55840 | 3,992 | |||
| PTF1A | pancreas | GEO | Mus musculus | GSE27295 | 40,017 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |