RAD51
Information RAD51
- Description
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:15834424). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (By similarity). {ECO:0000250|UniProtKB:Q06609, ECO:0000269|PubMed:15834424}.(Source UnitProtKB).
- Full Name
RAD51 recombinase
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 2
- Peaks
- 15,140
- Non-redundant peaks
- 14,275
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for RAD51
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| RAD51 | MEF | FHA | GEO | Mus musculus | GSE133805 | 2,052 | ||
| RAD51 | testis | GEO | Mus musculus | GSE34592 | 6,197 | |||
| RAD51 | MEF | 53BP1-S25A_FHA | GEO | Mus musculus | GSE133805 | 2,369 | ||
| RAD51 | MEF | WT_FHA | GEO | Mus musculus | GSE133805 | 1,218 | ||
| RAD51 | MEF | 53BP1-S25A | GEO | Mus musculus | GSE133805 | 3,304 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |