RB1

Information RB1

Description

Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:8336704). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587). Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation (PubMed:16612004). Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity) (PubMed:15750587, PubMed:16612004, PubMed:8336704). {ECO:0000250|UniProtKB:P06400, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:15750587, ECO:0000269|PubMed:16612004, ECO:0000269|PubMed:8336704}.(Source UnitProtKB).

Full Name

RB transcriptional corepressor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
1
Peaks
3,501
Non-redundant peaks
3,484

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19645
Official Gene Name
Rb1
JASPAR
MGI
MGI:97874
Ensembl
ENSMUSG00000022105
UniProt
P13405
Genevisible
P13405
RefSeq
NM_009029
Aliases
Rb; Rb-1; pRb; pp105; retinoblastoma 1
All peaks RB1
Download BED file
Non redundant peaks RB1
Download BED file
SEQUENCES RB1
Download FASTA file
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Datasets Table for RB1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RB1 MEF arrested GEO Mus musculus GSE77993 184
RB1 MEF arrested_SS GEO Mus musculus GSE77993 1,233
RB1 MEF arrested GEO Mus musculus GSE85639 2,084
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks