RB1

Information RB1

Description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Full Name

RB transcriptional corepressor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
7
Biotypes
4
Peaks
109,407
Non-redundant peaks
69,100

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
5925
Official Gene Name
RB1
JASPAR
Ensembl
ENSG00000139687
UniProt
P06400
Genevisible
P06400
RefSeq
NM_000321
Aliases
OSRC; PPP1R130; RB; p105-Rb; pRb; pp110
All peaks RB1
Download BED file
Non redundant peaks RB1
Download BED file
SEQUENCES RB1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for RB1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RB1 MCF-7 siH1-2 GEO Homo sapiens GSE98728 9,542
RB1 MCF-7 siGFP GEO Homo sapiens GSE98728 11,600
RB1 K-562 ENCODE Homo sapiens ENCSR506CVF 19,875
RB1 K-562 ENCODE Homo sapiens ENCSR670JDQ 25,268
RB1 GM12878 ENCODE Homo sapiens ENCSR916BOH 2,397
RB1 GM12878 ENCODE Homo sapiens ENCSR785OKZ 40,621
RB1 fibroblast SENESCENT GEO Homo sapiens GSE19898 104
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks