RBBP5
Information RBBP5
- Description
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (PubMed:21335234). Does not affect ES cell self-renewal (PubMed:21335234). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (By similarity). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). {ECO:0000250|UniProtKB:Q15291, ECO:0000269|PubMed:21335234}.(Source UnitProtKB).
- Full Name
retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 13,300
- Non-redundant peaks
- 13,300
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 213464
- Official Gene Name
- Rbbp5
- JASPAR
- MGI
- MGI:1918367
- Ensembl
- ENSMUSG00000026439
- UniProt
- Q8BX09
- Genevisible
- Q8BX09
- RefSeq
- NM_172517
- Aliases
- 4933411J24Rik