RBPJ

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity) (PubMed:18381292). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095). {ECO:0000250|UniProtKB:P28159, ECO:0000250|UniProtKB:Q06330, ECO:0000269|PubMed:18381292, ECO:0000269|PubMed:26194095, ECO:0000269|PubMed:7566092}.(Source UnitProtKB).

recombination signal binding protein for immunoglobulin kappa J region

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10