RBPJ

Information RBPJ

Description

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity) (PubMed:18381292). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095). {ECO:0000250|UniProtKB:P28159, ECO:0000250|UniProtKB:Q06330, ECO:0000269|PubMed:18381292, ECO:0000269|PubMed:26194095, ECO:0000269|PubMed:7566092}.(Source UnitProtKB).

Full Name

recombination signal binding protein for immunoglobulin kappa J region

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
11
Biotypes
9
Peaks
165,591
Non-redundant peaks
128,180

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19664
Official Gene Name
Rbpj
JASPAR
MGI
MGI:96522
Ensembl
ENSMUSG00000039191
UniProt
P31266
Genevisible
P31266
RefSeq
NM_009035
Aliases
AI843960; CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa; RBP-Jkappa; RBPjk; Rbpsuh
All peaks RBPJ
Download BED file
Non redundant peaks RBPJ
Download BED file
SEQUENCES RBPJ
Download FASTA file
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Datasets Table for RBPJ

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RBPJ neural-tube GEO Mus musculus GSE55840 6,600
RBPJ lymphoma T6E GEO Mus musculus GSE29600 5,509
RBPJ lymphoma G4A2 GEO Mus musculus GSE29600 13,345
RBPJ testicular-teratoma asynchronous GEO Mus musculus GSE45889 8,268
RBPJ pancreas GEO Mus musculus GSE47459 27,324
RBPJ kupffer-cell GEO Mus musculus GSE128658 19,553
RBPJ brain-pericytes GEO Mus musculus GSE120482 2,857
RBPJ leukemia GEO Mus musculus GSE66146 33,248
RBPJ testicular-teratoma mitosis GEO Mus musculus GSE45889 34,096
RBPJ spleen GEO Mus musculus GSE61504 10,151
RBPJ liver GEO Mus musculus GSE47459 4,640
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks