RCOR1

Information RCOR1

Description

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:15907476, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:20346398}.(Source UnitProtKB).

Full Name

REST corepressor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
3
Peaks
25,393
Non-redundant peaks
25,183

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
217864
Official Gene Name
Rcor1
JASPAR
MGI
MGI:106340
Ensembl
ENSMUSG00000037896
UniProt
Q8CFE3
Genevisible
Q8CFE3
RefSeq
NM_198023
Aliases
6720480E22Rik; D12Wsu95e; Rocr1
All peaks RCOR1
Download BED file
Non redundant peaks RCOR1
Download BED file
SEQUENCES RCOR1
Download FASTA file
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Datasets Table for RCOR1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RCOR1 MEL ENCODE Mus musculus ENCSR000ESI 19,499
RCOR1 CH12-LX ENCODE Mus musculus ENCSR000EQZ 1,146
RCOR1 mESC GEO Mus musculus GSE27841 4,748
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks