RCOR1
Information RCOR1
- Description
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:15907476, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:20346398}.(Source UnitProtKB).
- Full Name
REST corepressor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 3
- Peaks
- 25,393
- Non-redundant peaks
- 25,183
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 217864
- Official Gene Name
- Rcor1
- JASPAR
- MGI
- MGI:106340
- Ensembl
- ENSMUSG00000037896
- UniProt
- Q8CFE3
- Genevisible
- Q8CFE3
- RefSeq
- NM_198023
- Aliases
- 6720480E22Rik; D12Wsu95e; Rocr1
Datasets Table for RCOR1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
RCOR1 | MEL | ENCODE | Mus musculus | ENCSR000ESI | 19,499 | |||
RCOR1 | CH12-LX | ENCODE | Mus musculus | ENCSR000EQZ | 1,146 | |||
RCOR1 | mESC | GEO | Mus musculus | GSE27841 | 4,748 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |