REL

Information REL

Description

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity). {ECO:0000250}.

Full Name

reticuloendotheliosis oncogene

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
23,054
Non-redundant peaks
15,272

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19696
Official Gene Name
Rel
JASPAR
MGI
MGI:97897
Ensembl
ENSMUSG00000020275
UniProt
P15307
Genevisible
P15307
RefSeq
NM_009044
Aliases
c-Rel
All peaks REL
Download BED file
Non redundant peaks REL
Download BED file
SEQUENCES REL
Download FASTA file
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Datasets Table for REL

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
REL CD8-pos CpG GEO Mus musculus GSE106730 12,960
REL CD8-pos plC GEO Mus musculus GSE106730 10,094
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks