RELA

Information RELA

Description

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression (PubMed:29813070). Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (By similarity). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression (By similarity). {ECO:0000250|UniProtKB:Q04206, ECO:0000269|PubMed:21131967, ECO:0000269|PubMed:22244329, ECO:0000269|PubMed:29813070}.(Source UnitProtKB).

Full Name

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
102
Biotypes
13
Peaks
2,638,678
Non-redundant peaks
400,599

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19697
Official Gene Name
Rela
JASPAR
MGI
MGI:103290
Ensembl
ENSMUSG00000024927
UniProt
Q04207
Genevisible
Q04207
RefSeq
NM_009045
Aliases
p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB
All peaks RELA
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Non redundant peaks RELA
Download BED file
SEQUENCES RELA
Download FASTA file
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Datasets Table for RELA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RELA spleen GEO Mus musculus GSE98263 673
RELA T-cell stim_Treg GEO Mus musculus GSE99319 27,625
RELA T-cell stim_Tconv GEO Mus musculus GSE99319 22,828
RELA Th1 GEO Mus musculus GSE62482 28,384
RELA Treg GEO Mus musculus GSE99319 6,410
RELA MEF 0-5h_Rela-mut GEO Mus musculus GSE132863 38,071
RELA MEF 0h_Rela-mut GEO Mus musculus GSE132863 4,513
RELA MEF 0h GEO Mus musculus GSE132792 994
RELA primary-hepatocyte IL-1 GEO Mus musculus GSE96767 2,412
RELA BMDC 1h GEO Mus musculus GSE36099 24,983
RELA macrophage B6_Kdo2-LipidA GEO Mus musculus GSE46494 77,743
RELA macrophage g2 GEO Mus musculus GSE48759 519
RELA macrophage KLA-6h GEO Mus musculus GSE48759 15,377
RELA macrophage GEO Mus musculus GSE50944 8,198
RELA macrophage Flavo-7h GEO Mus musculus GSE48759 6,129
RELA macrophage GEO Mus musculus GSE48759 1,669
RELA macrophage NCor-KO_KLA-1h GEO Mus musculus GSE50944 39,208
RELA macrophage KLA-1h GEO Mus musculus GSE50944 47,519
RELA EL4 RA GEO Mus musculus GSE62482 8,926
RELA aorta VSMC_IFNa-LPS GEO Mus musculus GSE120806 55,414
RELA aorta VSMC_IFNg GEO Mus musculus GSE120806 12,185
RELA aorta VSMC_IFNa GEO Mus musculus GSE120806 9,176
RELA BMM GEO Mus musculus GSE54414 37,944
RELA BMDM 15min GEO Mus musculus GSE99895 30,300
RELA BMDM NOD GEO Mus musculus GSE109965 65,977
RELA BMDM 2h GEO Mus musculus GSE99895 36,338
RELA BMDM KLA4h_BMAL-KO GEO Mus musculus GSE95712 36,352
RELA BMDM KLA_PWK GEO Mus musculus GSE109965 62,229
RELA BMDM lipidA-15min GEO Mus musculus GSE67343 12,503
RELA BMDM KLA4h GEO Mus musculus GSE95712 40,880
RELA BMDM veh-6h GEO Mus musculus GSE72964 35,029
RELA BMDM lipidA-30min GEO Mus musculus GSE67343 11,506
RELA BMDM SREBF1-KO_KLA-6h GEO Mus musculus GSE79423 70,615
RELA BMDM KLA0h GEO Mus musculus GSE95712 499
RELA BMDM LPS-0h_Littermate-ctrl GEO Mus musculus GSE93599 158
RELA BMDM KLA12h_BMAL-KO GEO Mus musculus GSE95712 12,491
RELA BMDM KLA12h GEO Mus musculus GSE95712 12,737
RELA BMDM TGFb-6h GEO Mus musculus GSE72964 4,113
RELA BMDM IL4 GEO Mus musculus GSE106701 23,319
RELA BMDM KLA8h_BMAL-KO GEO Mus musculus GSE95712 204,019
RELA BMDM LPS-8h GEO Mus musculus GSE93599 3,802
RELA BMDM SPRET GEO Mus musculus GSE109965 10,475
RELA BMDM 30min_Irf3-KO GEO Mus musculus GSE99895 1,133
RELA BMDM lipidA-1h GEO Mus musculus GSE67343 17,495
RELA BMDM KLA8h GEO Mus musculus GSE95712 53,616
RELA BMDM LPS-8h_Dex3h-late GEO Mus musculus GSE93736 265
RELA BMDM KLA GEO Mus musculus GSE109965 58,164
RELA BMDM GEO Mus musculus GSE72964 6,671
RELA BMDM LPS GEO Mus musculus GSE109131 3,561
RELA BMDM lipidA-2h GEO Mus musculus GSE67343 5,919
RELA BMDM LPS-3h GEO Mus musculus GSE93736 8,801
RELA BMDM homog-6h GEO Mus musculus GSE72964 33,797
RELA BMDM LPS-DEX GEO Mus musculus GSE109131 3,710
RELA BMDM 1h GEO Mus musculus GSE99895 52,307
RELA BMDM 2h_Irf3-KO GEO Mus musculus GSE99895 33,017
RELA BMDM 1h_Irf3-KO GEO Mus musculus GSE99895 44,238
RELA BMDM KLA48h_BMAL-KO GEO Mus musculus GSE95712 2,212
RELA BMDM LPS-3h GEO Mus musculus GSE93599 8,800
RELA BMDM GEO Mus musculus GSE106701 20,201
RELA BMDM KLA-24h GEO Mus musculus GSE79423 68,665
RELA BMDM KLA24h_BMAL-KO GEO Mus musculus GSE95712 7,081
RELA BMDM 30min GEO Mus musculus GSE99895 37,492
RELA BMDM 15min_Irf3-KO GEO Mus musculus GSE99895 25,039
RELA BMDM LPS GEO Mus musculus GSE16723 28,796
RELA BMDM GEO Mus musculus GSE16723 988
RELA BMM LPS GEO Mus musculus GSE54414 7,139
RELA Th1 TBX21-KO GEO Mus musculus GSE62482 50,607
RELA T-cell Tconv GEO Mus musculus GSE99319 5,115
RELA aorta VSMC_IFNg-LPS GEO Mus musculus GSE120806 58,891
RELA aorta VSMC GEO Mus musculus GSE120806 6,045
RELA aorta VSMC_LPS GEO Mus musculus GSE120806 61,032
RELA BMDM KLA-6h GEO Mus musculus GSE72964 45,074
RELA BMDM LPS-3h_Littermate-ctrl GEO Mus musculus GSE93599 1,841
RELA BMDM KLA48h GEO Mus musculus GSE95712 1,426
RELA BMDM SREBF1-KO_KLA-24h GEO Mus musculus GSE79423 75,767
RELA BMDM LPS GEO Mus musculus GSE106701 40,118
RELA BMDM GEO Mus musculus GSE79423 47,003
RELA BMDM LPS-8h_Littermate-ctrl GEO Mus musculus GSE93599 1,357
RELA BMDM LPS-8h GEO Mus musculus GSE93736 3,801
RELA BMDM B6 GEO Mus musculus GSE109965 37,308
RELA BMDM GEO Mus musculus GSE109965 62,258
RELA BMDM GEO Mus musculus GSE109131 1,143
RELA BMDM KLA_B6 GEO Mus musculus GSE109965 62,851
RELA BMDM PWK GEO Mus musculus GSE109965 60,260
RELA BMDM GEO Mus musculus GSE67343 254
RELA BMDM Dex_LPS GEO Mus musculus GSE31796 17,981
RELA BMDM KLA0h_BMAL-KO GEO Mus musculus GSE95712 8,287
RELA BMDM KLA24h GEO Mus musculus GSE95712 11,817
RELA BMDM IL4-LPS GEO Mus musculus GSE106701 54,934
RELA BMDM SREBF1-KO GEO Mus musculus GSE79423 55,230
RELA macrophage NCor-KO GEO Mus musculus GSE50944 8,253
RELA macrophage KLA-1h GEO Mus musculus GSE48759 30,305
RELA macrophage Kdo2-LipidA GEO Mus musculus GSE46494 57,656
RELA macrophage DMSO-7h GEO Mus musculus GSE48759 7,701
RELA macrophage KLA-1h_g2 GEO Mus musculus GSE48759 44,582
RELA MEF 0-5h GEO Mus musculus GSE132863 56,054
RELA liver LPS GEO Mus musculus GSE117488 14,629
RELA liver saline GEO Mus musculus GSE117488 3,672
RELA liver SFD GEO Mus musculus GSE117488 29,011
RELA liver regular-chow GEO Mus musculus GSE117488 11,449
RELA BMDC 30min GEO Mus musculus GSE36099 9,188
RELA BMDC 2h GEO Mus musculus GSE36099 36,219
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks