RELB

Information RELB

Description

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (By similarity). {ECO:0000250|UniProtKB:Q01201, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22894897}.(Source UnitProtKB).

Full Name

avian reticuloendotheliosis viral (v-rel) oncogene related B

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
6,420
Non-redundant peaks
6,311

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19698
Official Gene Name
Relb
JASPAR
MGI
MGI:103289
Ensembl
ENSMUSG00000002983
UniProt
Q04863
Genevisible
Q04863
RefSeq
Aliases
shep
All peaks RELB
Download BED file
Non redundant peaks RELB
Download BED file
SEQUENCES RELB
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Datasets Table for RELB

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RELB BMDC 30min GEO Mus musculus GSE36099 310
RELB BMDC 2h GEO Mus musculus GSE36099 6,110
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks