REST

Information REST

Description

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:29961578, PubMed:9771705). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 2 (PubMed:21884984). Repressor activity may be inhibited by forming heterodimers with isoform 2, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (PubMed:15907476). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:27819263). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (PubMed:25727884). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q13127, ECO:0000269|PubMed:10490617, ECO:0000269|PubMed:11039732, ECO:0000269|PubMed:15907476, ECO:0000269|PubMed:21884984, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:25727884, ECO:0000269|PubMed:27819263, ECO:0000269|PubMed:29961578, ECO:0000269|PubMed:9771705}.; [Isoform 2]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than isoform 1 (PubMed:11039732). Exhibits weaker repressor activity compared to isoform 1 (By similarity). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11039732, PubMed:10490617). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (By similarity). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 2 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes, maintenance of hair cells and hearing (PubMed:29961578). {ECO:0000250|UniProtKB:Q13127, ECO:0000269|PubMed:10490617, ECO:0000269|PubMed:11039732, ECO:0000269|PubMed:29961578}.(Source UnitProtKB).

Full Name

RE1-silencing transcription factor

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
15
Biotypes
4
Peaks
136,198
Non-redundant peaks
65,474

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19712
Official Gene Name
Rest
JASPAR
MGI
MGI:104897
Ensembl
ENSMUSG00000029249
UniProt
Q8VIG1
Genevisible
Q8VIG1
RefSeq
NM_011263
Aliases
2610008J04Rik; AA407358; NRSF; REST4
All peaks REST
Download BED file
Non redundant peaks REST
Download BED file
SEQUENCES REST
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for REST

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
REST myocyte ENCODE Mus musculus ENCSR000AIS 2,489
REST mESC GEO Mus musculus GSE48320 2,130
REST mESC GEO Mus musculus GSE27148 3,135
REST mESC GEO Mus musculus GSE27841 15,741
REST mESC Snf2KO GEO Mus musculus GSE112132 1,797
REST bone-marrow shBcl11b GEO Mus musculus GSE110305 9,685
REST bone-marrow bcl11-KO GEO Mus musculus GSE110305 23,568
REST bone-marrow shctrl GEO Mus musculus GSE110305 20,573
REST bone-marrow GEO Mus musculus GSE110305 38,193
REST NPC GEO Mus musculus GSE27148 5,110
REST mESC addback GEO Mus musculus GSE112132 2,158
REST mESC Brg1fl GEO Mus musculus GSE112132 4,023
REST mESC addbackMut GEO Mus musculus GSE112132 2,001
REST mESC ctrl GEO Mus musculus GSE48122 3,972
REST mESC GEO Mus musculus GSE112132 1,623
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks