RFX6
Information RFX6
- Description
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (By similarity). {ECO:0000250|UniProtKB:Q8HWS3, ECO:0000269|PubMed:20148032}.(Source UnitProtKB).
- Full Name
regulatory factor X, 6
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 4,148
- Non-redundant peaks
- 4,148
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 320995
- Official Gene Name
- Rfx6
- JASPAR
- MGI
- MGI:2445208
- Ensembl
- ENSMUSG00000019900
- UniProt
- Q8C7R7
- Genevisible
- Q8C7R7
- RefSeq
- NM_177306
- Aliases
- 4930572O07Rik; Rfxdc1