RNF2

Information RNF2

Description

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). {ECO:0000269|PubMed:12183370, ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:16710298, ECO:0000269|PubMed:22226355, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:24034696, ECO:0000269|PubMed:28596365}.(Source UnitProtKB).

Full Name

ring finger protein 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
110
Biotypes
18
Peaks
1,506,751
Non-redundant peaks
350,134

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19821
Official Gene Name
Rnf2
JASPAR
MGI
MGI:1101759
Ensembl
ENSMUSG00000026484
UniProt
Q9CQJ4
Genevisible
Q9CQJ4
RefSeq
NM_011277
Aliases
AI326319; AI450156; AU019207; Ring1B; dinG
All peaks RNF2
Download BED file
Non redundant peaks RNF2
Download BED file
SEQUENCES RNF2
Download FASTA file
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Datasets Table for RNF2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RNF2 spleen KO GEO Mus musculus GSE42705 10,059
RNF2 NPC GEO Mus musculus GSE89929 18,837
RNF2 NPC GEO Mus musculus GSE96107 2,490
RNF2 NPC GEO Mus musculus GSE53540 8,103
RNF2 MEF EZHIP GEO Mus musculus GSE124741 3,751
RNF2 MEF K27-OE GEO Mus musculus GSE124741 5,563
RNF2 MEF GEO Mus musculus GSE124741 3,683
RNF2 MEF EED-null GEO Mus musculus GSE124741 2,931
RNF2 thymocyte GEO Mus musculus GSE33653 1,198
RNF2 forelimb-bud prox GEO Mus musculus GSE70076 14,929
RNF2 forelimb distal_EEDC-KO GEO Mus musculus GSE123630 30,463
RNF2 forelimb distal GEO Mus musculus GSE123630 28,575
RNF2 brain GEO Mus musculus GSE60409 1,770
RNF2 mesoderm-precursor GEO Mus musculus GSE67868 8,472
RNF2 mESC E882K GEO Mus musculus GSE77093 8,571
RNF2 mESC Y860H GEO Mus musculus GSE77093 9,251
RNF2 mESC K785R GEO Mus musculus GSE77093 11,363
RNF2 mESC 0h GEO Mus musculus GSE118399 11,639
RNF2 mESC 10-per-human-chrom GEO Mus musculus GSE126659 3,520
RNF2 mESC 2i-d1 GEO Mus musculus GSE72164 21,057
RNF2 mESC shNup153-2 GEO Mus musculus GSE64008 11,366
RNF2 mESC shNup153-4 GEO Mus musculus GSE64008 2,043
RNF2 mESC EPZ GEO Mus musculus GSE140894 51,616
RNF2 mESC GEO Mus musculus GSE41314 4,836
RNF2 mESC UNC4976 GEO Mus musculus GSE135762 32,291
RNF2 mESC GEO Mus musculus GSE83094 16,196
RNF2 mESC GEO Mus musculus GSE89929 20,907
RNF2 mESC GEO Mus musculus GSE64008 36,225
RNF2 mESC Bap1-KO GEO Mus musculus GSE120302 20,845
RNF2 mESC GEO Mus musculus GSE132752 22,505
RNF2 mESC 10-per-human-chrom_SA2-depleted GEO Mus musculus GSE126659 3,176
RNF2 mESC Tam GEO Mus musculus GSE77093 12,526
RNF2 mESC KO GEO Mus musculus GSE99530 5,150
RNF2 mESC GEO Mus musculus GSE78899 4,105
RNF2 mESC GEO Mus musculus GSE96107 8,879
RNF2 mESC I53SOHT GEO Mus musculus GSE134053 3,683
RNF2 mESC GEO Mus musculus GSE116603 4,884
RNF2 mESC GEO Mus musculus GSE135762 18,843
RNF2 mESC 5-per-human-chrom_SA2-depleted GEO Mus musculus GSE126659 5,073
RNF2 mESC 5-per-human-chrom_SA1-depleted GEO Mus musculus GSE126659 3,274
RNF2 mESC 10-per-human-chrom_SA1-depleted GEO Mus musculus GSE126659 3,445
RNF2 mESC E861K GEO Mus musculus GSE77093 9,200
RNF2 mESC DMSO GEO Mus musculus GSE140894 40,642
RNF2 mESC OHT GEO Mus musculus GSE83094 12,162
RNF2 mESC untreated GEO Mus musculus GSE52619 10,253
RNF2 mESC shKdm2b GEO Mus musculus GSE40860 16,141
RNF2 mESC GEO Mus musculus GSE71883 13,348
RNF2 mESC EZh2Y726D GEO Mus musculus GSE116603 33,791
RNF2 mESC Rest-KO GEO Mus musculus GSE48122 13,380
RNF2 mESC treated GEO Mus musculus GSE55697 21,403
RNF2 mESC WT GEO Mus musculus GSE77093 7,529
RNF2 mESC R885H GEO Mus musculus GSE77093 4,822
RNF2 mESC 2i GEO Mus musculus GSE72164 17,267
RNF2 mESC GEO Mus musculus GSE23716 7,215
RNF2 mESC GEO Mus musculus GSE72164 22,310
RNF2 mESC EtOH GEO Mus musculus GSE77093 5,415
RNF2 mESC PARETA GEO Mus musculus GSE134053 6,270
RNF2 mESC Kdm2bKO GEO Mus musculus GSE41314 4,410
RNF2 mESC Smarca4flfl_Tam GEO Mus musculus GSE77093 4,577
RNF2 mESC UNC3866 GEO Mus musculus GSE135762 23,151
RNF2 mESC NeuP GEO Mus musculus GSE64008 9,678
RNF2 mESC 12h GEO Mus musculus GSE118399 12,202
RNF2 mESC 72h GEO Mus musculus GSE118399 9,667
RNF2 mESC I53A GEO Mus musculus GSE69955 52,334
RNF2 mESC GEO Mus musculus GSE34518 23,885
RNF2 mESC shKdm2b GEO Mus musculus GSE37930 895
RNF2 mESC GEO Mus musculus GSE98723 3,640
RNF2 mESC GEO Mus musculus GSE74330 11,300
RNF2 mESC GEO Mus musculus GSE69955 15,250
RNF2 mESC Suz12-KO GEO Mus musculus GSE37930 709
RNF2 mESC GEO Mus musculus GSE42466 12,438
RNF2 EpiSC GEO Mus musculus GSE81203 1,665
RNF2 3T3-L1 GEO Mus musculus GSE64312 29,214
RNF2 3T3-L1 Kdm2b-V5 GEO Mus musculus GSE64312 60,574
RNF2 GSCs GEO Mus musculus GSE55060 8,685
RNF2 distal-forelimb GEO Mus musculus GSE129425 21,816
RNF2 TSC Airn-KO GEO Mus musculus GSE118399 5,525
RNF2 TSC VP160 GEO Mus musculus GSE118399 8,037
RNF2 mESC-E14 PCGF2-4-KO GEO Mus musculus GSE122715 15,405
RNF2 mESC-E14 PCGF3-5-KO GEO Mus musculus GSE122715 8,156
RNF2 mESC-E14 PCGF3-5-6-KO GEO Mus musculus GSE122715 4,304
RNF2 mESC-E14 PCGF1-KO GEO Mus musculus GSE122715 6,727
RNF2 L8057 induced GEO Mus musculus GSE33653 8,742
RNF2 L8057 uninduced GEO Mus musculus GSE33653 6,518
RNF2 EpiSC Wnt3a-5h GEO Mus musculus GSE81203 1,835
RNF2 forelimb-bud dis GEO Mus musculus GSE70076 22,412
RNF2 proximal-forelimb GEO Mus musculus GSE129425 17,212
RNF2 mESC-E14 PCGF6-KO GEO Mus musculus GSE122715 7,085
RNF2 mESC-E14 GEO Mus musculus GSE122715 6,899
RNF2 forelimb proximal GEO Mus musculus GSE123630 30,019
RNF2 forelimb proximal_EEDC-KO GEO Mus musculus GSE123630 40,181
RNF2 TSC VP160-noguide GEO Mus musculus GSE118399 7,361
RNF2 TSC Kcnq1ot1-KO GEO Mus musculus GSE118399 12,356
RNF2 cortical-neuron GEO Mus musculus GSE96107 1,077
RNF2 mESC treated GEO Mus musculus GSE52619 10,372
RNF2 mESC WT GEO Mus musculus GSE99530 6,365
RNF2 mESC TAM GEO Mus musculus GSE132752 24,870
RNF2 mESC Smarca4flfl_EtOH GEO Mus musculus GSE77093 10,915
RNF2 mESC UNC4219 GEO Mus musculus GSE135762 42,308
RNF2 mESC GEO Mus musculus GSE55697 16,945
RNF2 mESC GEO Mus musculus GSE120302 16,966
RNF2 mESC 2i-d3 GEO Mus musculus GSE72164 37,414
RNF2 mESC PARETA-OHT GEO Mus musculus GSE134053 1,554
RNF2 mESC shScr GEO Mus musculus GSE40860 20,300
RNF2 mESC EZH2-KO GEO Mus musculus GSE116603 4,988
RNF2 mESC OHT GEO Mus musculus GSE134053 5,960
RNF2 mESC ctrl GEO Mus musculus GSE48122 14,835
RNF2 mESC G784E GEO Mus musculus GSE77093 5,736
RNF2 L8057 Rnf2-alt-AB GEO Mus musculus GSE33653 6,114
RNF2 3T3-L1 dF-box GEO Mus musculus GSE64312 25,927
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks