RNF2
Information RNF2
- Description
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). {ECO:0000269|PubMed:12183370, ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:16710298, ECO:0000269|PubMed:22226355, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:24034696, ECO:0000269|PubMed:28596365}.(Source UnitProtKB).
- Full Name
ring finger protein 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 110
- Biotypes
- 18
- Peaks
- 1,506,751
- Non-redundant peaks
- 350,134
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 19821
- Official Gene Name
- Rnf2
- JASPAR
- MGI
- MGI:1101759
- Ensembl
- ENSMUSG00000026484
- UniProt
- Q9CQJ4
- Genevisible
- Q9CQJ4
- RefSeq
- NM_011277
- Aliases
- AI326319; AI450156; AU019207; Ring1B; dinG
Datasets Table for RNF2
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
RNF2 | spleen | KO | GEO | Mus musculus | GSE42705 | 10,059 | ||
RNF2 | NPC | GEO | Mus musculus | GSE89929 | 18,837 | |||
RNF2 | NPC | GEO | Mus musculus | GSE96107 | 2,490 | |||
RNF2 | NPC | GEO | Mus musculus | GSE53540 | 8,103 | |||
RNF2 | MEF | EZHIP | GEO | Mus musculus | GSE124741 | 3,751 | ||
RNF2 | MEF | K27-OE | GEO | Mus musculus | GSE124741 | 5,563 | ||
RNF2 | MEF | GEO | Mus musculus | GSE124741 | 3,683 | |||
RNF2 | MEF | EED-null | GEO | Mus musculus | GSE124741 | 2,931 | ||
RNF2 | thymocyte | GEO | Mus musculus | GSE33653 | 1,198 | |||
RNF2 | forelimb-bud | prox | GEO | Mus musculus | GSE70076 | 14,929 | ||
RNF2 | forelimb | distal_EEDC-KO | GEO | Mus musculus | GSE123630 | 30,463 | ||
RNF2 | forelimb | distal | GEO | Mus musculus | GSE123630 | 28,575 | ||
RNF2 | brain | GEO | Mus musculus | GSE60409 | 1,770 | |||
RNF2 | mesoderm-precursor | GEO | Mus musculus | GSE67868 | 8,472 | |||
RNF2 | mESC | E882K | GEO | Mus musculus | GSE77093 | 8,571 | ||
RNF2 | mESC | Y860H | GEO | Mus musculus | GSE77093 | 9,251 | ||
RNF2 | mESC | K785R | GEO | Mus musculus | GSE77093 | 11,363 | ||
RNF2 | mESC | 0h | GEO | Mus musculus | GSE118399 | 11,639 | ||
RNF2 | mESC | 10-per-human-chrom | GEO | Mus musculus | GSE126659 | 3,520 | ||
RNF2 | mESC | 2i-d1 | GEO | Mus musculus | GSE72164 | 21,057 | ||
RNF2 | mESC | shNup153-2 | GEO | Mus musculus | GSE64008 | 11,366 | ||
RNF2 | mESC | shNup153-4 | GEO | Mus musculus | GSE64008 | 2,043 | ||
RNF2 | mESC | EPZ | GEO | Mus musculus | GSE140894 | 51,616 | ||
RNF2 | mESC | GEO | Mus musculus | GSE41314 | 4,836 | |||
RNF2 | mESC | UNC4976 | GEO | Mus musculus | GSE135762 | 32,291 | ||
RNF2 | mESC | GEO | Mus musculus | GSE83094 | 16,196 | |||
RNF2 | mESC | GEO | Mus musculus | GSE89929 | 20,907 | |||
RNF2 | mESC | GEO | Mus musculus | GSE64008 | 36,225 | |||
RNF2 | mESC | Bap1-KO | GEO | Mus musculus | GSE120302 | 20,845 | ||
RNF2 | mESC | GEO | Mus musculus | GSE132752 | 22,505 | |||
RNF2 | mESC | 10-per-human-chrom_SA2-depleted | GEO | Mus musculus | GSE126659 | 3,176 | ||
RNF2 | mESC | Tam | GEO | Mus musculus | GSE77093 | 12,526 | ||
RNF2 | mESC | KO | GEO | Mus musculus | GSE99530 | 5,150 | ||
RNF2 | mESC | GEO | Mus musculus | GSE78899 | 4,105 | |||
RNF2 | mESC | GEO | Mus musculus | GSE96107 | 8,879 | |||
RNF2 | mESC | I53SOHT | GEO | Mus musculus | GSE134053 | 3,683 | ||
RNF2 | mESC | GEO | Mus musculus | GSE116603 | 4,884 | |||
RNF2 | mESC | GEO | Mus musculus | GSE135762 | 18,843 | |||
RNF2 | mESC | 5-per-human-chrom_SA2-depleted | GEO | Mus musculus | GSE126659 | 5,073 | ||
RNF2 | mESC | 5-per-human-chrom_SA1-depleted | GEO | Mus musculus | GSE126659 | 3,274 | ||
RNF2 | mESC | 10-per-human-chrom_SA1-depleted | GEO | Mus musculus | GSE126659 | 3,445 | ||
RNF2 | mESC | E861K | GEO | Mus musculus | GSE77093 | 9,200 | ||
RNF2 | mESC | DMSO | GEO | Mus musculus | GSE140894 | 40,642 | ||
RNF2 | mESC | OHT | GEO | Mus musculus | GSE83094 | 12,162 | ||
RNF2 | mESC | untreated | GEO | Mus musculus | GSE52619 | 10,253 | ||
RNF2 | mESC | shKdm2b | GEO | Mus musculus | GSE40860 | 16,141 | ||
RNF2 | mESC | GEO | Mus musculus | GSE71883 | 13,348 | |||
RNF2 | mESC | EZh2Y726D | GEO | Mus musculus | GSE116603 | 33,791 | ||
RNF2 | mESC | Rest-KO | GEO | Mus musculus | GSE48122 | 13,380 | ||
RNF2 | mESC | treated | GEO | Mus musculus | GSE55697 | 21,403 | ||
RNF2 | mESC | WT | GEO | Mus musculus | GSE77093 | 7,529 | ||
RNF2 | mESC | R885H | GEO | Mus musculus | GSE77093 | 4,822 | ||
RNF2 | mESC | 2i | GEO | Mus musculus | GSE72164 | 17,267 | ||
RNF2 | mESC | GEO | Mus musculus | GSE23716 | 7,215 | |||
RNF2 | mESC | GEO | Mus musculus | GSE72164 | 22,310 | |||
RNF2 | mESC | EtOH | GEO | Mus musculus | GSE77093 | 5,415 | ||
RNF2 | mESC | PARETA | GEO | Mus musculus | GSE134053 | 6,270 | ||
RNF2 | mESC | Kdm2bKO | GEO | Mus musculus | GSE41314 | 4,410 | ||
RNF2 | mESC | Smarca4flfl_Tam | GEO | Mus musculus | GSE77093 | 4,577 | ||
RNF2 | mESC | UNC3866 | GEO | Mus musculus | GSE135762 | 23,151 | ||
RNF2 | mESC | NeuP | GEO | Mus musculus | GSE64008 | 9,678 | ||
RNF2 | mESC | 12h | GEO | Mus musculus | GSE118399 | 12,202 | ||
RNF2 | mESC | 72h | GEO | Mus musculus | GSE118399 | 9,667 | ||
RNF2 | mESC | I53A | GEO | Mus musculus | GSE69955 | 52,334 | ||
RNF2 | mESC | GEO | Mus musculus | GSE34518 | 23,885 | |||
RNF2 | mESC | shKdm2b | GEO | Mus musculus | GSE37930 | 895 | ||
RNF2 | mESC | GEO | Mus musculus | GSE98723 | 3,640 | |||
RNF2 | mESC | GEO | Mus musculus | GSE74330 | 11,300 | |||
RNF2 | mESC | GEO | Mus musculus | GSE69955 | 15,250 | |||
RNF2 | mESC | Suz12-KO | GEO | Mus musculus | GSE37930 | 709 | ||
RNF2 | mESC | GEO | Mus musculus | GSE42466 | 12,438 | |||
RNF2 | EpiSC | GEO | Mus musculus | GSE81203 | 1,665 | |||
RNF2 | 3T3-L1 | GEO | Mus musculus | GSE64312 | 29,214 | |||
RNF2 | 3T3-L1 | Kdm2b-V5 | GEO | Mus musculus | GSE64312 | 60,574 | ||
RNF2 | GSCs | GEO | Mus musculus | GSE55060 | 8,685 | |||
RNF2 | distal-forelimb | GEO | Mus musculus | GSE129425 | 21,816 | |||
RNF2 | TSC | Airn-KO | GEO | Mus musculus | GSE118399 | 5,525 | ||
RNF2 | TSC | VP160 | GEO | Mus musculus | GSE118399 | 8,037 | ||
RNF2 | mESC-E14 | PCGF2-4-KO | GEO | Mus musculus | GSE122715 | 15,405 | ||
RNF2 | mESC-E14 | PCGF3-5-KO | GEO | Mus musculus | GSE122715 | 8,156 | ||
RNF2 | mESC-E14 | PCGF3-5-6-KO | GEO | Mus musculus | GSE122715 | 4,304 | ||
RNF2 | mESC-E14 | PCGF1-KO | GEO | Mus musculus | GSE122715 | 6,727 | ||
RNF2 | L8057 | induced | GEO | Mus musculus | GSE33653 | 8,742 | ||
RNF2 | L8057 | uninduced | GEO | Mus musculus | GSE33653 | 6,518 | ||
RNF2 | EpiSC | Wnt3a-5h | GEO | Mus musculus | GSE81203 | 1,835 | ||
RNF2 | forelimb-bud | dis | GEO | Mus musculus | GSE70076 | 22,412 | ||
RNF2 | proximal-forelimb | GEO | Mus musculus | GSE129425 | 17,212 | |||
RNF2 | mESC-E14 | PCGF6-KO | GEO | Mus musculus | GSE122715 | 7,085 | ||
RNF2 | mESC-E14 | GEO | Mus musculus | GSE122715 | 6,899 | |||
RNF2 | forelimb | proximal | GEO | Mus musculus | GSE123630 | 30,019 | ||
RNF2 | forelimb | proximal_EEDC-KO | GEO | Mus musculus | GSE123630 | 40,181 | ||
RNF2 | TSC | VP160-noguide | GEO | Mus musculus | GSE118399 | 7,361 | ||
RNF2 | TSC | Kcnq1ot1-KO | GEO | Mus musculus | GSE118399 | 12,356 | ||
RNF2 | cortical-neuron | GEO | Mus musculus | GSE96107 | 1,077 | |||
RNF2 | mESC | treated | GEO | Mus musculus | GSE52619 | 10,372 | ||
RNF2 | mESC | WT | GEO | Mus musculus | GSE99530 | 6,365 | ||
RNF2 | mESC | TAM | GEO | Mus musculus | GSE132752 | 24,870 | ||
RNF2 | mESC | Smarca4flfl_EtOH | GEO | Mus musculus | GSE77093 | 10,915 | ||
RNF2 | mESC | UNC4219 | GEO | Mus musculus | GSE135762 | 42,308 | ||
RNF2 | mESC | GEO | Mus musculus | GSE55697 | 16,945 | |||
RNF2 | mESC | GEO | Mus musculus | GSE120302 | 16,966 | |||
RNF2 | mESC | 2i-d3 | GEO | Mus musculus | GSE72164 | 37,414 | ||
RNF2 | mESC | PARETA-OHT | GEO | Mus musculus | GSE134053 | 1,554 | ||
RNF2 | mESC | shScr | GEO | Mus musculus | GSE40860 | 20,300 | ||
RNF2 | mESC | EZH2-KO | GEO | Mus musculus | GSE116603 | 4,988 | ||
RNF2 | mESC | OHT | GEO | Mus musculus | GSE134053 | 5,960 | ||
RNF2 | mESC | ctrl | GEO | Mus musculus | GSE48122 | 14,835 | ||
RNF2 | mESC | G784E | GEO | Mus musculus | GSE77093 | 5,736 | ||
RNF2 | L8057 | Rnf2-alt-AB | GEO | Mus musculus | GSE33653 | 6,114 | ||
RNF2 | 3T3-L1 | dF-box | GEO | Mus musculus | GSE64312 | 25,927 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |