RPA2

Information RPA2

Description

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

Full Name

replication protein A2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
1
Peaks
37,632
Non-redundant peaks
28,309

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
6118
Official Gene Name
RPA2
JASPAR
Ensembl
ENSG00000117748
UniProt
P15927
Genevisible
P15927
RefSeq
NM_001286076
Aliases
REPA2; RP-A p32; RP-A p34; RPA32
All peaks RPA2
Download BED file
Non redundant peaks RPA2
Download BED file
SEQUENCES RPA2
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for RPA2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RPA2 phospho HeLa shTOP1 GEO Homo sapiens GSE108172 8,232
RPA2 phospho HeLa GEO Homo sapiens GSE108172 18,963
RPA2 phospho HeLa shASF GEO Homo sapiens GSE108172 10,437
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks